Normal Pressure hydrocephalus (NPH) is characterized by gait apraxia, urinary incontinence, and dementia. Mixed connective tissue disease (MCTD) is an autoimmune connective tissue disease that has never been reported to cause NPH. Our patient was a 67-year man with a one-year history of gradual worsening gait and balance, urinary urgency with urge incontinence and decreased short-term memory. P...

Male BXSB mice spontaneously develop autoimmune disease with features similar to systemic lupus erythematosus. To determine whether this autoimmune disease can be treated as well as prevented by bone-marrow transplantation (BMT) and, at the same time, whether the immunity functions of lethally irradiated recipients can be reconstituted fully, male BXSB mice were engrafted with mixed T cell-depl...

Abstract Hop stunt viroid (HSVd) and Citrus tristeza virus (CTV) are the causal agents of most important diseases of citrus. Previously we reported a novel variant of HSVd that constantly associated with the yellow corky vein disease. Here, 19 individual citrus leaves with yellow corky vein symptoms were sampled for CTV by ELISA. In this study, most symptomatic samples were found to be inf...

The B cell is a vital contributor to humoral immunity. The B cell-specific antigen CD20 is expressed during B cell development, starting at the pre-B cell level and persists through B cell differentiation, but is lost during terminal differentiation to plasma cells. Rituximab is a monoclonal antibody that destroys both normal and malignant B cells that have CD20 on their surfaces and is ther...

rheumatoid arthritis is a chronic systemic inflammatory disease that affects approximately 0.5-1% of the world population. the current approach to this disease is to start an intensive treatment without delay once the disease has developed. various studies in the literature have shown that combination of disease modifying antirheumatic drugs such as sulfasalazine and chloroquine offers a more a...