نتایج جستجو برای: mmp 1
تعداد نتایج: 2762224 فیلتر نتایج به سال:
Matrix metalloproteinases in extracellular matrix remodeling: molecular, cellular and tissue aspects
Matrix metalloproteinases are an integral component of the organ-specific tissue microenvironment, primarily participating in regulation state integrative-buffer metabolic environment, remodeling, morphogenesis and immunogenesis, genesis pathological vascular diseases. Therefore, issues related to matrix metalloproteinase activity under altered gravity a matter high urgency for space biomedicin...
We examined the regulation of matrix metalloproteinase (MMP) production by mitogen-activated protein kinases and cyclooxygenases (COXs) in fibroblast-like synoviocytes (FLSCs). IL-1beta and TNF-alpha stimulated FLSC extracellular signal-regulated kinase (ERK) activation as well as MMP-1 and -13 release. Pharmacologic inhibitors of ERK inhibited MMP-1, but not MMP-13 expression. Whereas millimol...
Background: Metalloproteinase enzymes can lead to the digestion of the extracellular matrix and its compounds and ultimately facilitate the metastasis of cancer cells to other tissues. This study aimed to evaluate the activity of matrix metalloproteinases (MMPs) 1 and 13 in the tissue and plasma samples of the patients with breast cancer and their relationship with clinical features of the dise...
A series of phenyl piperidine alpha-sulfone hydroxamate derivatives has been prepared utilizing a combination of solution-phase and resin-bound library technologies to afford compounds that are potent and highly selective for MMP-13, are dual-sparing of MMP-1 and MMP-14 (MT1-MMP) and exhibit oral bioavailability in rats.
An artificial receptor for proMMP-9 was created by fusing tissue inhibitor of MMP-1 (TIMP-1) with type II transmembrane mosaic serine protease (MSP-T1). Expression of MSP-T1 in 293T cells induced binding of proMMP-9, which was processed by MMP-2 activated by membrane type 1 MMP (MT1-MMP). HT1080 cells transfected with the MSP-T1 gene produced activated MMP-9 in collagen gel, and addition of pro...
Kanwar, Yashpal S., Kosuke Ota, Qiwei Yang, Jun Wada, Naoki Kashihara, Yufeng Tian, and Elisabeth I. Wallner. Role of membrane-type matrix metalloproteinase 1 (MT-1-MMP), MMP-2, and its inhibitor in nephrogenesis. Am. J. Physiol. 277 (Renal Physiol. 46): F934–F947, 1999.— Extracellular matrix (ECM) proteins, their integrin receptors, and matrix metalloproteinases (MMPs), the ECMdegrading enzyme...
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