Purpose Lung cancer (LC) is the leading cause of cancer death worldwide. Evidences suggest that both LC cancer stem cells (CSCs) and cancer cells are supposed to be eliminated to achieve superior treatment effect against LC. Salinomycin could eradiate CSCs in various types of cancers, and gefitinib is a first-line therapy in LC. The purpose of the present study was to develop salinomycin-loaded...

The prevention of microbial surface contamination has become most crucial in today’s health care system, and in food and pharmaceutical production. Human beings are often infected by microorganisms such as bacteria, viruses, and molds that often infect living environments. Silver nanoparticles or silver ions have been known to have strong inhibitory and bactericidal effects. Metallic nanopartic...

Combination chemotherapy in clinical practice has been generally accepted as a feasible strategy for overcoming multidrug resistance (MDR). Here, we designed and successfully prepared a co-delivery system named S-D1@L-D2 NPs, where denoted some smaller nanoparticles (NPs) carrying a drug doxorubicin (DOX) were loaded into a larger NP containing another drug (vincristine [VCR]) via water-in-oil-...

Nanoparticles (NPs) are commonly used, and concerns about their possible adverse effects are being voiced as well. However, little is known about the fates of NPs released to the environment. The aim of the study was to (i) evaluate the ability of Sinapis alba and Lepidium sativum plants to take up platinum nanoparticles (Pt-NPs) and translocate them to aboveground organs, (ii) compare the accu...

BACKGROUND Newcastle disease (ND) is a highly contagious viral disease of poultry caused by pathogenic strains of the Newcastle disease virus (NDV). Live NDV vaccines are administered by drinking water, eyedrops or coarse aerosol spray. To further enhance mucosal immune responses, chitosan nanoparticles were developed for the mucosal delivery of a live NDV vaccine. METHODOLOGY/PRINCIPAL FINDI...

Copper nanoparticles (Cu NPs) supported on diamond nanoparticles (D NPs) previously purified by Fenton treatment (Cu/D) followed by annealing with hydrogen (Cu/DH) are highly efficient and reusable heterogeneous catalysts for hydrogenation of styrene to ethylbenzene with the minimum productivity value of 30,617 cycles.

(1) Background: Poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) loaded with Tobramycin were prepared using a solvent-evaporation method. (2) Methods: The NPs were coated with low molecular weight chitosan (LMWC) to enhance the mucoadhesiveness of PLGA-NPs. The following w/w ratios of tobramycin to LMWC were prepared: control (0:0.50), F₀ (1:0.25), F₀.₅ (1:0.5), and F₁ (1:1). (3) Result...

Nanoparticles (NPs) of zinc oxide (ZnO) and titanium dioxide (TiO2) are receiving increasing attention due to their widespread applications. The aim of this study was to evaluate the toxic effect of ZnO and TiO2 NPs at different concentrations (50, 100, 250 and 500 ppm) and compare them with their respective salts using a battery of cytotoxicity, and genotoxicity parameters. To evaluate cytotox...

An excellent gene vector is of great importance for the development of the gene therapy. Gelatin–siloxane nanoparticles (GS NPs) with controlled size and surface charge were synthesized through a two-step sol–gel process for gene vector. In order to increase the efficiency of tumour targeting, HIV-derived Tat peptide and TTA1, a kind of modified RNA aptamer, were further grafted onto GS NPs (GS...

BACKGROUND Increasing use of silver nanoparticles (Ag-NPs) in various products is resulting in a greater likelihood of human exposure to these materials. Nevertheless, little is still known about the influence of carbohydrates on the toxicity and cellular uptake of nanoparticles. METHODS Ag-NPs functionalized with three different monosaccharides and ethylene glycol were synthesized and charac...