T cell development from multipotent progenitors to specialized effector subsets of mature T cells is guided by the iterative action of transcription factors. At each stage, transcription factors interact not only with an existing landscape of histone modifications and nucleosome packing, but also with other bound factors, while they modify the landscape for later-arriving factors in ways that f...

Interventions following a transient ischemic attack are aimed at preventing a future episode or stroke. Hypertension, current smoking, obesity, physical inactivity, diabetes mellitus, and dyslipidemia are all well-known risk factors, and controlling these factors can have dramatic effects on transient ischemic attack and stroke risk. For patients presenting within 48 hours of resolution of tran...

We propose a strategy to achieve the fastest convergence in the Wang-Landau algorithm with varying modification factors. With this strategy, the convergence of a simulation is at least as good as the conventional Monte Carlo algorithm, i.e., the statistical error vanishes as 1/sqrt t, where t is a normalized time of the simulation. However, we also prove that the error cannot vanish faster than...

serum containing intrinsic factor antibody. The antibody serum itselfbinds a small amount ofvitamin B12. This is ignored by Gottlieb, Lau, Wasserman, and Herbert (1956). R0dbro, Christiansen, and Schwartz (1965) and Irvine, Cullen, Scarth, and Simpson (1968) use normal serum during the determination of total vitamin B12-binding capacity of the gastric juice to 'balance' the antibody serum. Howe...

We define a novel definition of the holographic light hadron jet by a separation of scales from plasma to jet, which leads to the re-emergence of the late-time Bragg peak in the instantaneous jet energy loss rate. We use the holographic energy loss of light quark and our new jet prescription in AdS/CFT to calculate the nuclear modification factor of jet for a brick of plasma (both static and ex...

PC12 is a nerve growth factor (NGF) responsive cell line which exhibits two classes of NGF receptors distinguishable by different kinetic rate constants, sensitivity to trypsin and resistance to Triton detergent solubilization. Whereas incubation of PC12 cells with wheat germ agglutinin (WGA) prior to addition of ‘“1NGF inhibits binding of NGF to both classes of receptors, treatment with WGA su...

BACKGROUND Although modifiable risk factors have been included in previous models that estimate or project breast cancer risk, there remains a need to estimate the effects of changes in modifiable risk factors on the absolute risk of breast cancer. METHODS Using data from a case-control study of women in Italy (2569 case patients and 2588 control subjects studied from June 1, 1991, to April 1...

Atherosclerotic cardiovascular diseases (CVDs) are the leading cause of death and disability in the United States. While multiple studies have demonstrated that modification of atherosclerotic cardiovascular risk factors (CVRFs) significantly reduces morbidity and mortality rates, clinical control of CVDs and CVRFs remains poor. By 2010, the American Heart Association seeks to reduce coronary h...