Abstract Saponins make up an important group of natural glycosidic compounds which are distinguished by triterpene or steroidal aglycone. Although widely distributed in terrestrial flora, especially higher plants, they can also be found some marine organisms. Cytotoxic activity is one the most frequently reported from a wide array pharmacological activities known for these metabolites. The curr...

Drugs are bioactive compounds originally discovered from chemical structures present in both the plant and animal kingdoms. These have ability to interact with molecules found our body, blocking them, activating or increasing decreasing their levels. Their actions allowed us cure diseases improve state of health, which has led increase longevity species. Among pharmacological activity produced ...

dacarbazine is an antitumor prodrug which is used for the treatment of malignant metastatic melanoma and hodgkin’s disease. it requires initial activation in liver through an n-demethylationreaction. the active metabolite prevents the progress of disease via alkylation of guanine bases in dna strands. in order to investigate the importance of imidazole ring and its dynamictautomerization in ant...

Dysfunction of β -glucocerebrosidase (GCase) has no hydrolytic activity in patients of Gaucher's disease and increasing the risk factor for Parkinson's disease occurrence. Pharmacological chaperone design has been used to treat with misfolded protein in related disease, which utilized a small compound to cause protein folding correctly. This study employed the world largest traditional Chinese ...

Background & Aim: Using pharmaceutical agents in treatment of aphasia has caught the attention of many neurologists and neuroscientists. This short review study has sought the role of pharmacotherapy in treatment of aphasia, a linguistic impairment after acquired brain lesions. The pharmacological principles and mechanisms related to the effects of drugs used in aphasia rehabilitation are point...

One of the unresolved problems on way to improving pharmacotherapy CNS diseases is development and creation technologies that allow drugs cross blood-brain barrier (BBB). The review discusses modern methods drug delivery CNS. advantages disadvantages main pharmacological strategies for directly overcoming BBB an alternative this are shown. New brain with damage (physical, chemical, etc.) withou...