Introduction: Image quality and accuracy of in vivo activity quantification in SPECT are affected by collimator penetration and scatter components, especially in high energy imaging. These phenomena highly depend on the collimator characteristic and photon energy. The presence of penetrated and scattered photons from collimator in SPECT images degrades spatial resolution, contr...

UNLABELLED We developed a novel integrated quad-modality system that included 3 molecular imaging methods (PET, SPECT, and fluorescence molecular imaging [FMI]) and 1 anatomic imaging modality (CT). This system could study various biologic processes in the same animal using multiple molecular tracers. In addition to the technology development, we also discussed the optimization strategy of the ...

OBJECTIVES Small animal imaging has recently been focused on basic nuclear medicine. We have designed and built a small animal SPECT imaging system using a semiconductor camera and a newly designed collimator. We assess the performance of this system for small object imaging. METHODS We employed an MGC 1500 (Acrorad Co.) camera including a CdTe semiconductor. The pixel size was 1.4 mm/pixel. ...

specialty of nuclear medicine is living and well. The number of scientific presentations at the annual meeting of the Society of Nuclear Medicine (SNM) in the United States has increased linearly over the past half century. The excitement and progress resulting from the application of the tra-cer principle in living human beings continues. Oncology is still the major topic in nuclear medicine, ...

OBJECTIVE To assess the clinical utility of SPECT/ CT in subjects with endocrine and neuroendocrine tumors compared to SPECT alone. MATERIAL AND METHODS 48 subjects (31 women;17 men; mean age 54±11) with clinical suspicion or diagnosis of endocrine and neuroendocrine tumor had 50 SPECT/CT scans (32 Tc-99m MIBI, 5 post treatment I-131, 8 In-111 Pentetreotide, and 5 I-123 MIBG). SPECT alone fin...

The past four decades have seen enormous efforts placed on a search for molecular markers of schizophrenia using positron emission tomography (PET) and single photon computed (SPECT). In this narrative review, we cast broad net to define summarize what researchers learned about from imaging studies. Some PET studies brain energy metabolism with the glucose analogue FDGhave shown hypofrontality ...

BACKGROUND The aim of this study is to assess whether ultra-fast acquisition SPECT/CT (UF-SPECT/CT) can replace standard SPECT/CT (std-SPECT/CT) as "add-on" to whole-body bone scintigraphy (WB-BS) for the investigation of bone metastases. Consecutive cancer patients referred for WB-BS who underwent SPECT/CT in addition to WB-BS were included. Std-SPECT, UF-SPECT, and low-dose CT were performed ...

Acclaimed surgeons from Brazil, Canada, Japan, Turkey, the USA, and the UK are contributors. The book starts with a historical overview, epidemiology, molecular pathogenesis, cytogenetics, local invasion and metastasis, and pathology. A thorough discussion covers diagnostic radiological and radionuclide imaging such as MRI, PET; SPECT, PET-CT, and PET-MRI, and clinical traits of skull base and ...

Hypoxia, a deficiency in the levels of oxygen, is common feature most solid tumors and induces many characteristics cancer. Hypoxia associated with metastases strong resistance to radio- chemotherapy, can decrease accuracy cancer prognosis. Non-invasive imaging methods such as positron emission tomography (PET) single-photon computed (SPECT) using hypoxia-targeting radiopharmaceuticals have bee...

Single Photon Emission Computed Tomographic images(SPECT) have relatively poor resolution. In an attempt to improve SPECT image quality, many methods have been developed for including anatomic information, extracted from higher resolution, structurally correlated Magnetic Resonance images(MRI), into SPECT reconstruction process. These methods provide improved SPECT reconstruction accuracy if th...