A new specific, accurate, precise, and reproducible selective online dissolution method for rosiglitazone maleate is developed and validated for the dissolution of rosiglitazone maleate in pharmaceutical formulations. The rationale of the method is based on the direct measurement of the absorbance of the analyte in the buffer medium at 242 nm using buffer as blank. Dissolution is achieved on a ...

Dissolution behaviour of pure cefprozil monohydrate (CM) and cefuroxime axetile (CA) and their marketed tablets have been studied in aqueous as well as micellar media. Dissolution of cefprozil monohydrate is significantly assisted in presence of sodium dodecyl sulphate (SDS) and cetyltrimethylammonium bromide (CTAB). But, SDS and CTAB behave differently in accelerating the dissolution tendency ...

Hydrolysis of pyrosulfate was studied by electrochemical experiments and quantum mechanical calculations, revealing Gibbs transfer energies for pyrosulfate, hydrogen sulfate anions at the liquid-liquid interface.

Various commercially available paracetamol tablets (500 mg) were evaluated comparatively for in vitro dissolution qualities along with drug content (assay). The assay results ascertain the presence and compendial quality of paracetamol in all these products. The in vitro dissolution profiles were found to be varying for each tablet, but within the prescribed limit. The dissolution at 15 minutes...

Ethylenediamine tetraacetate (EDTA)-mediated calcite dissolution occurs via a different process than water-promoted dissolution. Near-atomic-scale observations in EDTA solutions demonstrate that, after penetration through a critical pit depth barrier, step velocity increases linearly with pit depth for EDTA-promoted dissolution. The parallel processes of water-dominated dissolution at point def...

Meloxicam is a poorly water soluble non steroidal anti-inflammatory drug and antipyretic agent. The aim of the present work was to investigate the effect of different types of carriers on in vitro dissolution of meloxicam. Meloxicam solid dispersions were prepared by physical mixing, co-grinding and solvent evaporation methods with polyethylene glycol (PEG) 6000. The effect of solubilization by...

Diosmin, a vascular-protecting agent, is practically insoluble in water, and its oral absorption is limited by its extremely low dissolution rate. In this study, β-cyclodextrin (βCD) and 2-hydroxypropyl-β-cyclodextrin (HPβCD) were obtained to improve the solubility and dissolution rate of diosmin. Phase solubility studies of diosmin with βCD and HPβCD in distilled water were conducted to charac...