Bevirimat [BVM, PA-457, 3-O-(3',3'-dimethylsuccinyl)-betulinic acid], a new anti-human immunodeficiency virus drug candidate, is metabolized to two monoglucuronides [mono-BVMG (I) and mono-BVMG (II)] and one diglucuronide (di-BVMG) both in vivo and in vitro. UDP-glucuronosyltransferase (UGT) reaction screening, enzyme kinetics, and species differences for the glucuronidation of BVM in vitro wer...

the degree of aromaticity of mono-substituted derivatives of benzene has beeninvestigated using a new index based on electric field gradient index, by using two mechanicalquantum methods with gaussian 03. two different basis sets have applied to study and theresults compared. this strategy has demonstrated that, due to violation of symmetry in have pisystems,how the degree of aromaticity can ha...

PKD1 and PKD2 mutations could lead to autosomal dominant polycystic kidney disease (ADPKD), which afflicts millions of people worldwide. Due to the marked differences in the lifespan, size, anatomy, and physiology from humans, rodent ADPKD models cannot fully mimic the disease. To obtain a large animal model that recapitulates the disease, we constructed a mini-pig model by mono-allelic knockou...

(maximum: 200 words, word count: 200 words) Purpose: The IntraVoxel Incoherent Motion (IVIM) MRI signal, typically described as a mono-exponential decay, can sometimes be better modeled as a bi-exponential function accounting for two vascular pools, capillaries and medium-size vessels. The goal of this work is to define precisely in which conditions the IVIM signal shape becomes bi-exponential ...

The study assessed 12-month chronic pain (CP)-related health care utilization and costs among chronic noncancer pain (CNCP) patients who initiated various long-term opioid treatments. Treatments included monotherapy with long-acting opioids (mono-LAOs), mono-therapy with short-acting opioids (mono-SAOs), both LAOs and SAOs (combination), and opioid therapy initiated with SAO or LAO and switched...

Poly(amidoamine) (PAMAM) dendrimer-based nanodevices are of recent interest in targeted cancer therapy. Characterization of mono- and multifunctional PAMAM-based nanodevices remains a great challenge because of their molecular complexity. In this work, various mono- and multifunctional nanodevices based on PAMAM G5 (generation 5) dendrimer were characterized by UV-Vis spectrometry, (1)H NMR, si...

Abstract: Parkinson's disease (PD) and Alzheimer's disease (AD), two of the most common neurodegenerative diseases, are caused by both genetic and environmental factors. Mammalian neuronal cells abundantly express a deubiquitinating (DUB) enzyme, Ubiquitin Carboxy-terminal hydrolase L1 (UCH-L1), which is involved in the pathogenesis of both of these neurodegenerative diseases. This DUB is selec...

Growth in the first year of life may already be predictive of obesity later in childhood. The objective was to assess the association between prenatal exposure to various endocrine disrupting chemicals (EDCs) and child growth during the first year. Dichloro-diphenyldichloroethylene (DDE), mono(2-ethyl-5-carboxypentyl)phthalate (MECPP), mono(2-ethyl-5-hydroxyhexyl)phthalate (MEHHP), mono(2-ethyl...

The Sanitation Districts of Los Angeles County (Districts) operate 11 wastewater treatment facilities. Ten of these facilities are classified as water reclamation plants (WRPs) producing approximately 200 million gallons per day (MGD) of reclaimed water suitable for reuse. The Districts' Palmdale WRP treats approximately 10 MGD using primary treatment followed by stabilization ponds. This facil...