Since the introduction of monoamine oxidase inhibitors (MAOIs) in the 1950s, researchers have been searching for antidepressant agents with more favorable tolerability profiles. The introduction of selective serotonin reuptake inhibitors (SSRIs) in the late 1980s provided clinicians with a drug class featuring an improved tolerability profile as compared to MAOIs and tricyclic antidepressants (...

Submit Manuscript | http://medcraveonline.com Abbreviations: TCAs: Tricyclic Antidepressants; SSRIs: Selective Serotonin-Reuptake Inhibitors; MAOIs: Monoamine Oxidase Inhibitors; SNRI: Serotonin-Norepinephrine Reuptake Inhibitor; PMDD: Premenstrual Dysphoric Disorder; SAD: Seasonal Affective Disorder; PMS: Premenstrual Syndrome; NE: Norepinephrine; 5-HT: 5-Hydroxytryptamine; DA: Dopamine; CNS: ...

The two forms of monoamine oxidase (MAO), A and B, continue to be of major interest to biochemists, pharmacologists, neurologists, and gerontologists. Despite intensive study for more than half a century, unexpected and unique properties of these enzymes continue to come to light. Recent studies have centered on their kinetic mechanism, their unique predilection for substrates related to the ne...

abstract in the present study, eleven compounds (1-11) including nine alkaloids (1-9), one triterpenoid saponin (10) and one formamide (11) were isolated from talaromyces sp. lgt-2, an endophytic fungus from tripterygium wilfordi. their structures were determined based on nmr and esi-ms spectral data, as well as comparing with previous literature data. this is the first report of the isolation ...