نتایج جستجو برای: monocarboxylic acid

تعداد نتایج: 747538  

Journal: :Diabetes 2006
Graeme F Mason Kitt F Petersen Vincent Lebon Douglas L Rothman Gerald I Shulman

We hypothesized that increased capacity for brain utilization of nonglucose substrates (monocarboxylic acids [MCAs]) by upregulation of the MCA transporters may contribute metabolic substrates during hypoglycemia. To test this hypothesis, we assessed brain acetate metabolism in five well-controlled type 1 diabetic subjects and six nondiabetic control subjects using 13C magnetic resonance spectr...

Journal: :The Journal of pharmacology and experimental therapeutics 2006
Qi Wang Inger M Darling Marilyn E Morris

Intoxication with gamma-hydroxybutyrate (GHB) is associated with coma, seizure, and death; treatment of overdoses is symptomatic. Previous studies in our laboratory have demonstrated that L-lactate and pyruvate treatment can increase the renal clearance of GHB and increase its elimination in rats, suggesting that GHB may undergo renal reabsorption mediated by monocarboxylic acid transporters (M...

Journal: :Cellulose 2022

High CO2 concentration in atmosphere causes serious environmental issues, and carbon capture storage technologies have attracted attention as a means to reduce the atmospheric concentration. Metal-organic frameworks (MOFs) can potentially be used for adsorption, but their poor stability microporosity limit applications. Herein, novel strategy was proposed combine cellulose aerogel hierarchicall...

Journal: :American journal of physiology. Regulatory, integrative and comparative physiology 2014
Teye Omlin Karolanne Langevin Jean-Michel Weber

Intense swimming causes circulatory lactate accumulation in rainbow trout because lactate disposal (Rd) is not stimulated as strongly as lactate appearance (Ra). This mismatch suggests that maximal Rd is limited by tissue capacity to metabolize lactate. This study uses exogenous lactate to investigate what constrains maximal Rd and minimal Ra. Our goals were to determine how exogenous lactate a...

Journal: :The Journal of clinical investigation 1991
R K Kundu J H Tonsgard G S Getz

The accumulation of dicarboxylic acids, particularly long chain, is a prominent feature of Reye's syndrome and diseases of peroxisomal metabolism. We assessed the omega-oxidation of a spectrum of fatty acids in rats and asked whether pretreatment of rats with aspirin, which is known to predispose children to Reye's syndrome, would affect omega-oxidation of long chain fatty acids. We found that ...

Journal: :Journal of bacteriology 1999
C D Holyoak D Bracey P W Piper K Kuchler P J Coote

Growth of Saccharomyces cerevisiae in the presence of the weak-acid preservative sorbic acid results in the induction of the ATP-binding cassette (ABC) transporter Pdr12 in the plasma membrane (P. Piper, Y. Mahe, S. Thompson, R. Pandjaitan, C. Holyoak, R. Egner, M. Muhlbauer, P. Coote, and K. Kuchler, EMBO J. 17:4257-4265, 1998). Pdr12 appears to mediate resistance to water-soluble, monocarboxy...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2017
Rui Wu Ruslan Sanishvili Boris R Belitsky Jose I Juncosa Hoang V Le Helaina J S Lehrer Michael Farley Richard B Silverman Gregory A Petsko Dagmar Ringe Dali Liu

The Bacillus subtilis protein regulator of the gabTD operon and its own gene (GabR) is a transcriptional activator that regulates transcription of γ-aminobutyric acid aminotransferase (GABA-AT; GabT) upon interactions with pyridoxal-5'-phosphate (PLP) and GABA, and thereby promotes the biosynthesis of glutamate from GABA. We show here that the external aldimine formed between PLP and GABA is ap...

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