Helicobacter pylori (Hp) is a human pathogen that lives in the gastric mucosa of approximately 50% world's population causing gastritis, peptic ulcers, and cancer. An increase resistance to current drugs has sparked search for new Hp drug targets therapeutics. One target disruption nucleic acid production, which can be achieved by impeding synthesis 6-oxopurine nucleoside monophosphates, precur...

Pyrimidine nucleoside monophosphate kinase (EC 2.7.4.14) catalyzes the phosphorylation of various pyrimidine nucleoside monophosphates to their corresponding diphosphates. In addition to its role in the synthesis of nucleic acid precursors, this enzyme is essential for the conversion of the antileukemic agent 1-/3-o-arabinofuranosylcytosine to its active metabolite 1-/3-o-arabinofuranosyl 5 -tr...