The Effect of Substance P on Ovariectomy-induced Memory Deficits in Rats Jamie L. Haga The present experiment was designed to test whether pretreatment with substance P would affect ovariectomy-induced memory deficits in rats for retention in the Morris water maze. Adult female Sprague-Dawley rats were divided to two groups: (1) control (received saline) and (2) experimental group (received sub...

objective(s) we determined the effect of a high fructose diet either alone or in combination with iranian shallot or garlic extract on cognitive functions, plasma lipid profile, and the intraperitoneal glucose tolerance test (ipgtt). materials and methods following induction of insulin resistance in fructose-fed rats (fru-fed), they were randomly assigned to three subgroups. the first subgroup ...

introduction: previous studies have shown that vitamin a and its derivatives such as retinoid and all-trans retinoic acid have a crucial role in memory, learning and synaptic plasticity. the receptors of vitamin a are seen in different parts of the brain such as hippocampus, where vitamin a has an important role in learning. in this study, the effect of intrahippocampal (ca1) injection of all –...

introduction: there are several evidences that show various environmental stresses during pregnancy, affect physiological behavior of the offspring. in this study the effects of rem (rapid eye movement) sleep deprivation of pregnant rats on spatial learning of adult male offspring by morris water maze were investigated. methods: water tank technique was used for inducing rem sleep deprivation. ...

objective(s): due to the prevalence and pervasiveness of stress in modern life and exposure to both chronic and acute stresses, it is not clear whether prior exposure to chronic stress can influence the impairing effects of acute stress on memory retrieval. this issue was tested in this study. materials and methods: adult male wistar rats were randomly assigned to the following groups: control,...

introduction: it has been reported that oral morphine dependency facilitated formation of spatial learning and memory. in the present study the role of nmda receptors located in hippocampal ca1 area of morphine dependent rats was studied. methods: male rats were divided into 4 groups. two cannulae were stereotaxically implanted bilaterally into the hippocampal ca1 area. after 5 days recovery, a...

The present study was designed to evaluate the effect of palmatine on memory of Swiss young male albino mice. Palmatine (0.1, 0.5, 1 mg/kg, i.p.) and physostigmine (0.1 mg/kg, i.p.) per se were administered for 10 successive days to separate groups of mice. Effect of drugs on learning and memory of mice was evaluated using elevated plus maze and Morris water maze. Brain acetylcholinesterase act...

The Morris water maze represents the de-facto standard for testing hippocampal function in laboratory rodents. In the field of adult hippocampal neurogenesis, however, using this paradigm to assess the functional relevance of the new neurons yielded surprisingly inconsistent results. While some authors found aspects of water maze performance to be linked to adult neurogenesis, others obtained d...

Objective(s) Learning is defined as the acquisition of information and skills, while subsequent retention of that information is called memory. The objective of the present study was to investigate the effect of aqueous extract of Boswellia papyrifera on learning and memory paradigms in mice and rats. Materials and Methods This study was held at the Department of Pharmacology, Faculty of Pha...