نتایج جستجو برای: morris water maze mwm

تعداد نتایج: 564005  

2015
Yanchun Zhang Zhihui Li Yan Gao Chenggang Zhang

The recent rapid development of electronic communication techniques is resulting in a marked increase in exposure of humans to electromagnetic fields (EMFs). This has raised public concerns about the health hazards of long-term environmental EMF exposure for fetuses and children. Some studies have suggested EMF exposure in children could induce nervous system disorders. However, gender-dependen...

Journal: :Pharmacology 2011
Ipek Komsuoglu Celikyurt Furuzan Yildiz Akar Guner Ulak Oguz Mutlu Faruk Erden

BACKGROUND/AIMS The aim of this study was to investigate the effects of an atypical antipsychotic risperidone (RIS; 0.06, 0.125 or 0.25 mg/kg, intraperitoneal, i.p.) on learning and memory processes, both in naive and MK-801-treated (0.15 mg/kg, i.p.) rats. METHODS Modified elevated plus maze (mEPM), passive avoidance (PA) and Morris water maze (MWM) tasks were used. RESULTS In the mEPM tes...

Journal: :International journal of clinical and experimental medicine 2015
Xing-Wang Chen Yong-Tao Lv Ye Han Ying Huan Xiao-Ya Feng Chun-Fu Chen

Neovibsanins are believed to be promising candidates for the development of novel therapeutic agents to treat neurological diseases like Alzheimer's disease. It has been shown that chronic cerebral hypoperfusion is linked to neurodegenerative disorders and their subsequent cognitive impairment. In the present study effect of neovibsanin B (NVB) on spatial cognitive functions of rats with lobal ...

Journal: :physiology and pharmacology 0
mohammad rasoul ghadami dept. of physiology, school of medicine, kermanshah university of medical sciences, kermanshah ali pourmotabbed dept. of physiology, school of medicine, kermanshah university of medical sciences, kermanshah

introduction: the cholinergic system plays an important role in learning and memory. administration of either extracts of crocus sativus (saffron) or its constituent, crocin, reduced ethanol-induced memory impairment. based on the above findings, we investigated the effect of crocin in antagonizing spatial learning and memory impairment induced by scopolamine, a cholinergic receptor antagonist,...

hojjatalah alaei, hplamreza ghavipanjeh, reihaneh hoveida, shahrbanoo oryan,

Introduction: Previous studies have shown that exercise enhances cognitive and functional capacities in patients with Alzheimer's disease (AD). In this study, we investigated the effect of long-term (60 days) and short- term (10 days) exercise on the spatial memory deficits in an animal model of AD. Methods: Fifty male rats were divided into 5 groups 1) intact, 2) sham, 3) sham-Alzheimer 4) ...

Introduction: The cholinergic system plays an important role in learning and memory. Administration of either extracts of Crocus Sativus (Saffron) or its constituent, crocin, reduced ethanol-induced memory impairment. Based on the above findings, we investigated the effect of crocin in antagonizing spatial learning and memory impairment induced by scopolamine, a cholinergic receptor antagoni...

Journal: :iranian biomedical journal 0
سمیه اسدیان نارنجی somayeh assadian narenji ناصر نقدی nasser naghdi شهربانو عریان shahrbano oryan کیهان آزادمنش kayhan azadmanesh

background: testosterone and its metabolites have important roles in learning and memory. the current study has conducted to assess the effect of pre-training, post-training and pre-probe trial intrahippocampal ca1 administration of 3 alpha-anderostanediol (one of the metabolites of testosterone) and indomethacin (as 3 alpha-hydroxysteroid dehydrogenase enzyme blocker) on acquisition, consolida...

Background & Objective: Prenatal seizures cause neuronal damage in the limbic area of fetal brain leading to learning deficits and cognitive impairment in newborns. This study examined the effect of prenatal tonic-clonic seizure and lithium chloride (LiCl) therapy on the learning and memory of rat’s pups. Materials & Methods: Pregnant Wistar rats were kindled by (i.p) injections of 40 mg/kg/BW ...

Journal: :Neurobiology of learning and memory 1997
M D Lindner

In the present study, F-344 rats throughout 1.5 to 26 months of age were tested in the reference memory version, a moving-platform repeated acquisition version, and in a cued platform version of the Morris water maze. The results suggest that: (1) performance in the water maze declines continuously, beginning at the earliest age, and very closely fits a linear function; (2) there are robust, re...

2014
Fatemeh Ghahremanitamadon Siamak Shahidi Somayeh Zargooshnia Ali Nikkhah Akram Ranjbar Sara Soleimani Asl

Alzheimer's disease (AD) is a neurodegenerative disorder and most common form of dementia that leads to memory impairment. In the present study we have examined the protective effects of Borago officinalis (borage) extract on Amyloid β (A β)-Induced memory impairment. Wistar male rats received intrahippocampal (IHP) injection of the A β (25-35) and borage extract throughout gestation (100 mg/kg...

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