Host resistance to infection depends on the efficiency with which innate immune responses keep the infectious agent in check. Innate immunity encompasses components with sensing, signaling and effector properties. These elements with non-redundant functions are encoded by a set of host genes, the resistome. Here, we review our findings concerning the resistome. We have screened randomly mutagen...

Abstract Natural killer (NK) cells are critical for the first line of defense against viral infection and malignancy. While transcriptional epigenetic regulation activated NK is well characterized in mice, these processes not yet fully understood human cells. We performed a targeted CRISPR/Cas9 ribonucleoprotein (RNP) transcription factor screen mature primary to identify putative factors requi...

Recently, using polymerase chain reaction (PCR) technique, the DNA of cytomegalovirus was detected from depigmented white patches in patients with vitiligo. The reactivation of infection and occasional anti-CMV IgM circulating among patients infected by cytomegalovirus has been reported for years. We have studied 26 patients with clinical signs and symptoms of vitiligo, some of whom had a ...

OBJECTIVES Low-dose valganciclovir prophylaxis is still under investigation in renal transplant procedures. Our aim was to assess the cost effectiveness of 450 mg versus 900 mg valganciclovir prophylaxis in kidney transplant recipients. MATERIALS AND METHODS In this prospective trial, 201 kidney transplant patients were randomized (1:1) to receive 450 mg/d (group 1, n = 100) or 900 mg/d (grou...

background and aims: cytomegalovirus (cmv) is a member of herpesviruses. it is one of the most common cause of congenital and prenatal infections. cmv infection of pregnant women, especially in the first trimester may lead to congenital abnormalities in the newborns. the prevalence of cmv infection in developed countries is about 40% and in developing countries may be 100%. because there is no ...

results the mean ages in case and control groups were 60.8 ± 6.8 and 57.5 ± 11.5 years, respectively, with no significant difference (p = 0.09). thirty patients (54.5%) in case and 32 (58.2%) in control groups were male with no significant difference (p = 0.7). cmv-dna was present in 8 (14.5%) of the cases and 2 (4%) of the controls. cmv-dna was associated with higher risk of atherosclerosis (o...

CMV can cause life-threatening disease in immunodeficient hosts. Experimental infection in mice has revealed that the genetically determined natural resistance to murine CMV (MCMV) may be mediated either by direct recognition between the NK receptor Ly49H and the pathogen-encoded glycoprotein m157 or by epistatic interaction between Ly49P and the host MHC H-2D(k). Using stocks of wild-derived i...

OBJECTIVES Cytomegalovirus infection is an important cause of morbidity and mortality among recipients undergoing hematopoietic stem cell and solid-organ transplant. The risk of cytomegalovirus infection is high in cytomegalovirus-seronegative recipients of cytomegalovirus-seropositive organs (donor positive/recipient negative) and recipients with strong immunosuppressive status such as those r...