Abstract Background The role of epigenetic events in gliomagenesis is undoubtful. However, the specific pathological not so clear. It was shown that loss total DNA methylation correlates with higher tumor malignancy and oxidative damage. But promoter many genes reported to be significant for gliomas’ predictive treatment outcome. In carcinogenesis general global hypomethylation focal hypermethy...

1. The presence and characteristics of P2X receptors on neurons of the rat major pelvic ganglia (MPG) have been studied using whole cell voltage-clamp, in situ hybridization and immunohistochemistry. 2. Rapid application of ATP (100 microM) to isolated rat MPG neurons induced moderately large inward currents (0.33-5.3 nA) in 39% of cells (108/277). The response to ATP occurred very rapidly, wit...

We examined whether cGMP-dependent protein kinase (PKG) and mitochondrial ATP-sensitive potassium (K(ATP)) channels are involved in S-nitroso-N-acetyl penicillamine (SNAP)-induced reactive oxygen species (ROS) generation. SNAP significantly increased ROS generation in cardiomyocytes. This increase was suppressed by both 5-hydroxydecanoate (5-HD) and glibenclamide. Direct opening of mitochondria...

To identify the major factors predicting the response to Methotrexate (MTX) therapy in rheumatoid arthritis (RA) patients, we evaluated the relationship between the response to MTX and factors such as the concentration of MTX-polyglutamates (MTX-PGs) in erythrocytes (RBCs), genotypes of thymidylate synthase (TYMS) 5'-UTR (2R/3R) and 3'-UTR (-6/+6), 5,10-methylenetetrahydrofolate reductase (MTHF...

Matching Pennies game (MPG) and and Rock-Paper-Scissors game (RPS) are the two elementary games. These two games are used to illustrate the concept (mixed strategy Nash equilibrium) since its very begin of the modern game theory. Under the traditional multi-person random pairwise-matching experimental protocol, using the definitive measurement, we have found the processes not in equilibrium but...

The synthesis of primary anilines via sustainable methods remains a challenge in organic synthesis. We report photocatalytic protocol for the selective cross-coupling wide range aryl/heteroaryl halides with sodium azide using photocatalyst powder consisting nickel(II) deposited on mesoporous carbon nitride (Ni-mpg-CNx). This heterogeneous contains high surface area visible light-absorbing and a...

This paper presents an out-of-plane electrostatic micro-power generator (MPG). Electret-based continuous MPGs with different gaps and masses are fabricated to demonstrate the merits of this topology. Experimental results of the MPG demonstrate output power of 1 mW for a base acceleration amplitude and frequency of 0.08 g and 86 Hz. The MPGs also demonstrate a wideband harvesting bandwidth reach...

Shuhua Xu and Li Jin* Chinese Academy of Sciences and Max Planck Society (CAS-MPG) Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Chinese Academy of Sciences, Shanghai 200031, China; State Key Laboratory of ...

OBJECTIVES/HYPOTHESIS To examine outcomes following midline posterior glossectomy (MPG) plus lingual tonsillectomy (LT) for the treatment of significant obstructive sleep apnea (OSA) in children with Down syndrome (DS). METHODS Patients with DS who had persistent OSA following tonsillectomy and adenoidectomy (TA) and were relatively intolerant of positive airway pressure (PAP) therapy were ev...

BACKGROUND Previous studies have shown a single linear relationship between mean plasma glucose (MPG) and hemoglobin A(1c) (HbA(1c)). We examined the relationship in different treatment groups of patients with type 1 diabetes participating in the Diabetes Control and Complications Trial (DCCT). METHODS Seven-point glucose profiles (premeal, postmeal, and bedtime) and HbA(1c) were measured qua...