The role of gamma-aminobutyric acid-A (GABAA) and GABAC receptors in the GABA-induced biphasic response in neurons of the rat major pelvic ganglia (MPG) were examined in vitro. Application of GABA (100 microM) to MPG neurons produced a biphasic response, an initial depolarization (GABAd) followed by a hyperpolarization (GABAh). The input resistance of the MPG neurons was decreased during the GA...

Introducción: la predisposición hereditaria causada por mutaciones patogénicas de línea germinal (MPG) explica hasta el 10% los cánceres mama. Para reducir su impacto en mujeres mutadas se han propuesto diferentes estrategias, tales como las cirugías reductoras riesgo o screening con resonancia magnética (RM) mamas.Métodos: este estudio observacional retrospectivo analizaron registros portadora...

Fractional anisotropy (FA) is the most commonly used quantitative measure of diffusion in the brain. Changes in FA have been reported in many neurological disorders, but the implementation of diffusion tensor imaging (DTI) in daily clinical practice remains challenging. We propose a novel color look-up table (LUT) based on normative data as a tool for screening FA changes. FA was calculated for...

Microgrids are an effective solution to decentralize electrical grids and improve usage of distributed energy resources (DERs). Within a microgrid there multiple active players it can be computationally expensive consider all their interactions. An optimal scheduler ensures that the needs within met without wasting electricity. With higher requirements for electric vehicle charging stations (EV...

BACKGROUND Discordance between small aortic valve area (AVA; < 1.0 cm(2)) and low mean pressure gradient (MPG; < 40 mm Hg) affects a third of patients with moderate or severe aortic stenosis (AS). We hypothesized that this is largely due to inaccurate echocardiographic measurements of the left ventricular outflow tract area (LVOTarea) and stroke volume alongside inconsistencies in recommended t...

For decades, computational intelligence techniques have been developed and applied to many real world problems. In this paper, tree architectures of fuzzy neural networks are applied to Auto MPG prediction problem. The dataset concerns city-cycle fuel consumption in miles per gallon, to be predicted in terms of 3 multivalued discrete and 5 continuous attributes. Tree architectures of fuzzy neur...

This paper describes the staged evolution of a complex motor pattern generator (MPG) for the control of a walking robot. The MPG is composed of a network of neurons with weights determined by Genetic Algorithm (GA) optimization. Staged evolution is used to improve the convergence rate of the algorithm. First, an oscilla-tor for the individual leg movements is evolved. Then, a network of these o...

The possible coexistence of nitric oxide (NO) and acetylcholine in the rat major pelvic ganglion (MPG) was examined by double immunohistochemistry using antisera raised against NO synthase (NOS) and choline acetyltransferase (ChAT). The smooth muscle responses of the isolated bladder and urethra were recorded after bilateral cryoganglionectomy of the MPG, focusing on the possible development of...

Erectile dysfunction is a common complication for patients undergoing surgeries for prostate, bladder, and colorectal cancers, due to damage of the nerves associated with the major pelvic ganglia (MPG). Functional re-innervation of target organs depends on the capacity of the neurons to survive and switch towards a regenerative phenotype. PDE5 inhibitors (PDE5i) have been successfully used in p...

This study was aimed at investigating the effects of sperm centrifugation on nitric oxide (NO) and reactive oxygen species (ROS) generation as well as sperm motility and viability. Human spermatozoa were centrifuged for 10 and 30 minutes (400 x g) in the presence or absence of the NOS inhibitor, N G -nitro-L-arginine methyl ester (L-NAME); ROS scavenger, N-(2-mercaptopropionyl)Glycine (MPG) or ...