This application note describes the analysis of selected designer drugs in urine after a very simple, fast and non-selective dilution step. Besides identification of the analytes by two or three MRM transitions, an information dependent acquisition (IDA) approach was used for automatically triggering enhanced product ion (EPI) scans after detection with one MRM transition per analyte. EPI spect...

In landscape genetics, model selection procedures based on Information Theoretic and Bayesian principles have been used with multiple regression on distance matrices (MRM) to test the relationship between multiple vectors of pairwise genetic, geographic, and environmental distance. Using Monte Carlo simulations, we examined the ability of model selection criteria based on Akaike's information c...

Amyotrophic lateral sclerosis (ALS) is characterized by selective degeneration of motor neurons. Current imaging studies have concentrated on areas of the brain and spinal cord that contain mixed populations of sensory and motor neurons. In this study, ex vivo magnetic resonance microimaging (MRM) was used to separate motor and sensory components by visualizing individual dorsal and ventral roo...

Aim Mycoplasma pulmonis (MP) remains potentially important rodent pathogen causing murine respiratory mycoplasmosis (MRM) which may go undiagnosed due to its asymptomatic nature. In the present study, we carried out clinical, pathological, and molecular investigations of MP-induced MRM in a rat colony. Materials and Methods Two female Wistar rats were observed to be diseased in animal facilit...

Cumulative dose-response curves to carbachol given by aerosol were established using plethysmographic measurements of specific airways resistance (SRaw) in 10 patients with asthma and five healthy subjects. Two experiments were performed--a control test and one in which maximal respiratory manoeuvres (MRM) (two maximal inspirations and two maximal expirations) were made before each carbachol in...

Quantitative targeted proteomics has recently taken front stage in the proteomics community. Centered on multiple reaction monitoring-mass spectrometry (MRM-MS) methodologies, quantitative targeted proteomics is being used in the verification of global proteomics data, the discovery of lower abundance proteins, protein post-translational modifications, discrimination of select highly homologous...

Characterizing the normal distribution of cerebrospinal fluid (CSF) in the spine is crucial for an accurate assessment of CSF leakage and other abnormalities. Magnetic resonance myelography (MRM) is a noninvasive diagnostic method that is commonly used to evaluate the spinal distribution of CSF. Our aim was to evaluate the anatomical distribution of CSF in the spine of healthy individuals, by M...

Background: Modified radical mastectomy (MRM) is still one of globally accepted surgical techniques for breast cancer and in some selected patient is the gold standard type of surgery. The most frequent complication of this procedure is seroma under skin flaps or in the axilla as reported as much as 30% in some studies. The use of closed suction drainage system to reduce the incidence of this c...

RATIONALE A pedicle pectoralis major musculocutaneous (PMMC) flap is one of the strategies for head and neck reconstruction. Seldom studies reported the case in which the skin area of previous modified radical mastectomy (MRM) had been used as a PMMC flap in head and neck reconstruction. PATIENT CONCERNS An 84-year-old female who had suffered from left breast cancer and undergone a left modif...