Background In this study, we aimed to investigate the effects of polymorphisms in genes encoding 1-carbon metabolism enzymes on differential development of metabolic parameters during 12 weeks of treatment with second-generation antipsychotics in first-episode schizophrenia patients. Methods The following polymorphisms in 1-carbon metabolism genes were genotyped: MTHFR (C677T and A1298C), MTH...

background: migraine consisting of migraine with aura (ma) and migraine without aura (mo) is a painful neurovascular disorder affecting approximately 16% of the general population. a combination of genetic and environmental factors is involved in the pathogenesis of migraine. the mthfr enzyme is involved in homocysteine (hcy) metabolism and it has been reported that 1298 a to c and 677 c to t m...

BACKGROUND Glutathione S-transferases (GSTM1, GSTT1, and GSTP1) and methylenetetrahydrofolate reductase (MTHFR) are important enzymes for protection against oxidative stress. In addition, MTHFR has an essential role in DNA synthesis, repair, and methylation. Their polymorphisms have been implicated in the pathogenesis of ulcerative colitis (UC). The aim of the present study was to investigate t...

multiple sclerosis (ms) is a demyelinating neuro- inflammatory autoimmune disease of the central nervous system. genetic predisposition has long been suspected in the etiology of this disease. the association between mthfr polymorphisms and ms has been ivestigated in different ethnic groups. we investigated the association between mthfr c677t and a1298c missense variants and ms in 180 patients ...

background: methylenetetrahydrofolate reductase (mthfr) single-nucleotide polymorphisms (snps) c677t and a1298c have been described as strong risk factors for idiopathic recurrent miscarriage (rm). however, very few studies have investigated the association of paternal mthfr snps with rm. the aim of the present study was to evaluate the prevalence of paternal c677t and a1298c snps among iranian...

Major congenital malformations occur in about 3% of newborn. Several studies have suggested that homozygosity for the C677T methylenetetrahydrofolate reductase (MTHFR) variant is a potential risk factor for neural tube defects (NTDs). It has been hypothesized that the maternal folic acid supplementation prevents NTDs by partially correcting reduced MTHFR activity associated with the variant for...

Previous studies have suggested that low folate intake is associated with increased risk of lung cancer. Methylenetetrahydrofolate reductase (MTHFR) is one of the enzymes involved in folate metabolism and is thought to influence DNA methylation and nucleotide synthesis. MTHFR is highly polymorphic, and the variant genotypes result in decreased MTHFR enzyme activity and lower plasma folate level...

Previous studies have suggested that low folate intake is associated with increased risk of lung cancer. Methylene-tetrahydrofolate reductase (MTHFR) is one of the enzymes involved in folate metabolism and is thought to influence DNA methylation and nucleotide synthesis. MTHFR is highly polymorphic, and the variant genotypes result in decreased MTHFR enzyme activity and lower plasma folate leve...

A significant portion of patients treated for pediatric acute lymphoblastic leukemia (ALL) relapse. We hypothesized that common polymorphisms with moderate effect sizes and large attributive risks could explain an important fraction of ALL relapses. Methylenetetrahydrofolate reductase (MTHFR) is central to folate metabolism and has two common functional polymorphisms (C677T and A1298G). Methotr...