Molla Sadra, pek çok eserinde sıkça Antik Yunan filozoflarına atıfta bulunur ve Nefis bahsi bunların önde gelenlerindendir. Bu makalede, Sadra’nın en önemli eseri Esfâr’dan bir bölüm üzerinde durulacaktır. Esfâr’ın 4.sefer 5. bab 6 faslında Antiklerin nefse dair görüşlerini, İbn Sina’nın Şifa Kitabındaki özeti esas alarak aktarır. Sonrasında ise bu teorileri tekrar yorumlar anlamlandırır eleşti...

OBJECTIVE Quantifying the relationship between microelectrode-recorded multi-unit activity (MUA) and local field potentials (LFPs) in distinct brain regions can provide detailed information on the extent of functional connectivity in spatially widespread networks. These methods are common in studies of cognition using non-human animal models, but are rare in humans. Here we applied a neuronal s...

Slow oscillations originating in the prefrontal neocortex during slow-wave sleep (SWS) group neuronal network activity and thereby presumably support the consolidation of memories. Here, we investigated whether the grouping influence of slow oscillations extends to hippocampal sharp wave-ripple (SPW) activity thought to underlie memory replay processes during SWS. The prefrontal surface EEG and...

Recent studies demonstrated that the anatomical network of the human brain shows a "rich-club" organization. This complex topological feature implies that highly connected regions, hubs of the large-scale brain network, are more densely interconnected with each other than expected by chance. Rich-club nodes were traversed by a majority of short paths between peripheral regions, underlining thei...

The phage Mu transposase (MuA) binds to the ends of the Mu genome during the assembly of higher order nucleoprotein complexes. We investigate the structure and function of the MuA end-binding domain (Ibetagamma). The three-dimensional solution structure of the Ibeta subdomain (residues 77-174) has been determined using multidimensional NMR spectroscopy. It comprises five alpha-helices, includin...

Purpose: Pharmacological fMRI is an increasingly used tool to assess and map drug-induced changes of neural activity. Brain function is typically probed by comparing blood oxygen level dependant (BOLD) signals before and after drug administration. In analogy to fMRI pharmacologically induced BOLD signal changes are thought to reflect respective changes in neuronal activity, despite additional d...

Debate has raged over whether a cruciate retaining (CR) or a posterior stabilised (PS) total knee replacement (TKR) provides a better range of movement (ROM) for patients. Various sub-sets of CR design are frequently lumped together when comparing outcomes. Additionally, multiple factors have been proven to influence the rate of manipulation under anaesthetic (MUA) following TKR. The purpose of...