STATEMENT OF THE PROBLEM Over the past three decades, significant improvements have been achieved in the survival of children with cancer. However, the considerable morbidity which occurs as a result of chemotherapy often restricts the treatment intensity. One of the important dose-limiting and costly adverse effects of cancer therapy is mucositis. Children with hematological malignancies are g...

BACKGROUND Mucositis is a highly significant, and sometimes dose-limiting, toxicity of cancer therapy. The goal of this systematic review was to update the Multinational Association of Supportive Care in Cancer and International Society of Oral Oncology (MASCC/ISOO) Clinical Practice Guidelines for mucositis. METHODS A literature search was conducted to identify eligible published articles, b...

This study investigated the prophylactic effects of orally administered surface-deacetylated chitin nanofibers (SDACNFs) and chitosan against 5-fluorouracil (5-FU)-induced intestinal mucositis, which is a common side effect of 5-FU chemotherapy. SDACNFs and chitosan abolished histological abnormalities associated with intestinal mucositis and suppressed hypoproliferation and apoptosis of intest...

Inflammation of the mucous membranes of the gastrointestinal tract, or mucositis, can impair the quality of life and treatment of patients with cancer. Mucositis is a particularly common problem in this population due to the use of chemotherapy and radiation with curative or palliative intent. Many patients who receive standard-dose chemotherapy experience some degree of mucositis, while most p...

Oral mucositis (OM) is an inflammatory condition affecting oral mucosa. The etiology of this type of inflammation is associated with exposure to radiotherapy or chemotherapeutic drugs. Herbal drug has been used to induce healing of different types of gastrointestinal ulcers. The role of medicinal plant in cancer therapy induced oral mucositis has been investigated extensively. Preclinical studi...

AIM To determine if almond extracts reduce the severity of chemotherapy-induced mucositis as determined through biochemical, histological and behavioural markers. METHODS Intestinal mucositis is a debilitating condition characterized by inflammation and ulceration of the gastrointestinal mucosa experienced by cancer patients undergoing chemotherapy. Certain bioactive plant products have shown...

La quimioterapia povoca una serie de efectos adversos sobre la cavidadoral, incuyendo xerostomía disfagia, y mucositis. El abordaje terapeutico los mucosa oral son insuficientes por programas salud. Las terapias complementarias surgen como alternativa para contrarrestar causados durante post cavidad oral. proposito este trabajo es analizar el posible uso las mucositis provocada convencional uti...

background: to investigate the effect of zinc sulphate for prophylaxis of radiation-induced oral mucositis in patients with head and neck cancer. materials and methods: in the department of radiation oncology, ankara numune education and research hospital, 40 patients with head and neck cancer were selected randomly to receive either zinco-c 25 mg, four tablets daily or control group who did no...

BACKGROUND Oral mucositis is a complication of intensive chemotherapy and radiotherapy with no effective treatment. We tested the ability of palifermin (recombinant human keratinocyte growth factor) to decrease oral mucosal injury induced by cytotoxic therapy. METHODS This double-blind study compared the effect of palifermin with that of a placebo on the development of oral mucositis in 212 p...

The incidence of severe mucositis in the oral cavity, pharynx and larynx is high among patients with head and neck cancer (HNC) receiving chemoradiotherapy (CRT), resulting in significant pain and impairment of quality of life. The present study investigated whether L-glutamine (glutamine) decreases the severity of mucositis in the oral cavity, pharynx and larynx induced by CRT. This double-bli...