Mutations were introduced into conserved steroidogenic factor 1 (SF1)- and SOX9-binding sites within the endogenous mouse Mullerian inhibiting substance (Mis) promoter. Male mice homozygous for the mutant SF1-binding site correctly initiated Mis transcription in fetal testes, although at significantly reduced levels. Surprisingly, sufficient MIS was produced to eliminate the MUllerian ducts. In...

Abstract Background Mullerian duct anomalies are a broad spectrum of congenital the female genital tract presenting with variable symptoms like infertility, amenorrhoea, dysmenorrhea, pelvic endometriosis, and poor obstetric outcomes. Unicornuate uterus or hemiuterus occurs as result abnormal formation failure contralateral part. Case presentation We present rare case report functional non-comm...

Persistent Mullerian Duct Syndrome (PMDS), a rare form of male pseudohermaphroditism, is characterized by the persistence of Mullerian duct structures (uterus, fallopian tubes and upper two-thirds of vagina) in otherwise normallyvirilized males (Karyotype 46XY). Patients suffering from PMDS present with cryptorchidism, inguinal hernia and infertility. Diagnosis is established when Mullerian duc...

Only five cases of recurrence of malignant mixed Mullerian tumor (carcinosarcoma) from the ovarian carcinoma have been published in the literature to our knowledge. A 64-year-old woman first underwent a total abdominal hysterectomy and bilateral salpingo-oophorectomy because of pelvic mass. Histological diagnosis was serous papillary carcinoma of the left ovary. After six courses of chemotherap...

INTRODUCTION Persistent Mullerian duct syndrome (PMDS) is a rare type of pseudohermaphroditism in genotypically and phenotypically males. They have a uterus, fallopian tubes, and upper part of the vagina; but Mullerian duct fails to regress. In transverse testicular ectopia (TTE), one of the testis moves to the opposite side and both testes pass the same inguinal canal. We report a case of PMDS...

Introduction: Congenital uterine anomalies are common but their effect on reproductive outcome is unclear. result from abnormal formation, fusion or resorption of mullerian ducts during fetal life. The overall frequency 4%. In general fertile population the 5%, in infertile 3%. Recurrent miscarriages occur 5-10% cases. Materials and methods:A hospital based cross-sectional analytical study was ...

Mullerian adenosarcoma of the cervix is a rare tumor composed of benign epithelial and malignant stromal components. Sarcomatous overgrowth and heterologous elements in cervical adenosarcoma are extremely infrequent. We report the case of a 26-year-old woman admitted at the gynaecology department for a painless mass protruding from her vagina. The initial pathological exam concluded to endocerv...

CONTEXT Malignant mixed Mullerian tumors are rare ovarian neoplasms that account for less than 2% of ovarian malignancies. They have a generally poor prognosis and often develop recurrent disease. To our knowledge, this is the first report of a malignant mixed Mullerian tumor with metastasis to the pancreas. The metastatic tumor was identified by endoscopic ultrasound guided fine needle aspirat...

Mullerian duct anomalies (MDAs) are congenital defects of the female genital system that arise from the abnormal embryological development of the Mullerian ducts.1,2 These abnormalities include a wide range of developmental anomalies, resulting from failure of development, defective fusion or defects in regression of the septum during fetal development. A review of the prevalence of different t...