OBJECTIVE Adverse event reports (AERs) submitted to the US Food and Drug Administration (FDA) were reviewed to confirm the platinum agent-associated mild, severe, and lethal hypersensitivity reactions. METHODS Authorized pharmacovigilance tools were used for quantitative signal detection, including the proportional reporting ratio, the reporting odds ratio, the information component given by ...

benzo[b][1,4]oxazines have been synthesized in good to excellent yields in the presence of the ionic liquid 1-butyl-3methylimidazolium bromide [bmim]Br under relatively mild conditions without any added catalyst, the reaction workup is simple and the ionic liquid can be easily separated from the product and reused. Keywords—Isocyanide, Benzo[b][1,4]oxazines, Multi-component reactions, [bmim]Br,...

The paper deals with the analysis of a model multi-component fluid admitting chemical reactions. flow is considered in incompressible regime. main result shows global existence regular solutions under assumption suitable smallness conditions. In order to control special structure condition on derivatives production functions determining reactions required. shown new critical functional framewor...

Multi-component reactions for the construction of heterocycles have been fascinated by microwave energy as an alternative technique heating, owing to advantages over traditional reflux methods. The heterogeneous catalysts contribute significantly towards recycling, harmless, easy filtration, catalyst preparation, more life span, abundance, and product yields. With novel creative uses in organic...

the analytical theory of one dimensional, dispersion free miscible displacement of oil by injection gas with nc component has shown that: the mmp is the lowest pressure at which any one of the initial oil, injection gas or crossover key tie lines becomes critical, which means that its length approaches to zero. in this paper, we propose a method for a solving multi component system based on ana...

based on driving force for crystallization of one-component gas hydrate, in this report an expression for the supersaturation for crystallization of multicomponent gas hydrate is derived. expressions for the supersaturation are obtained in isothermal and isobaric regimes. the results obtained are applied to the crystallization of hydrates of mixtures of methane plus ethane and can apply to othe...