One important issue associated with the complexity of dynamically evolving material interface is the scale-dependent dynamics which implies very different physical phenomena depending on the resolvability of the material interface. In this work we present a concept of multi-scale modeling where the interface interaction is modeled as being in mechanical non-equilibrium or in equilibrium, depend...

The Harris group proposed to develop significantly higher efficiency thin film multi-junction solar cells by combining multi-junctions and advanced nano-scale light management concepts in ultra-thin film devices that lend themselves to very large scale, low cost manufacturing. In the past year, they developed thin-film nanostructured solar cell modeling, epitaxial growth and fabrication. A nano...

A multi-scale modeling approach is proposed in this paper that assists the user in constructing musculoskeletal system models from sub-models describing various mechanisms on different levels on the length scale. In addition, dynamic time-scale analysis has been performed on the developed multi-scale models of various parts of a human limb: on wrist, elbow and shoulder characterized by differen...

A common reductionist assumption is that macro-scale behaviors can be described "bottom-up" if only sufficient details about lower-scale processes are available. The view that an "ideal" or "fundamental" physics would be sufficient to explain all macro-scale phenomena has been met with criticism from philosophers of biology. Specifically, scholars have pointed to the impossibility of deducing b...

Computational modeling has significantly impacted our ability to analyze vast (and exponentially increasing) quantities of experimental data for a variety of applications, such as drug discovery and disease forecasting. Single-scale, single-class models persist as the most common group of models, but biological complexity often demands more sophisticated approaches. This review surveys modeling...