Objectives: Accurately identifying the Antigens (Ags) on recipient red blood cells (RBCs) is critical in prevention of RBC alloimmunization in chronically transfused patients. The goal of this study was to compare RBC molecular genotyping to serological phenotyping in those patients. Methods: Serological phenotyping and molecular genotyping methods were used to study blood samples from 18 healt...

Regular blood transfusion is one of the most important and emergency treatment methods for thalassemia patients. This category patients considered sensitive to infection because their continued survival linked transfusion, therefore possibility great, especially in light war deterioration health services Yemen. Among this hepatitis B virus, which causes serious complications such as acute hepat...

The purpose of this study was to retrospectively evaluate the efficacy a tranexamic acid (TXA) perioperative protocol for primary hip- and knee arthroplasty, in terms allogenic blood transfusion rates. A retrospective cohort conducted included all hip arthroplasty procedures period 2014-2019. Patients who underwent surgery due trauma or revision were excluded. total amount 5205 patients eligibl...

Despite the general view that patients with sickle-cell disease (SCD) have iron overload, there are reports of iron deficiency in a proportion of these patients. We studied Yemeni patients aged 1-30 years with homozygous SCD to determine their iron status using a set of 4 criteria (low serum iron, low transferrin saturation, high total iron binding capacity and low mean corpuscular volume for a...

Patients with Glanzmann thrombasthenia (GT) may form isoantibodies which induce refractoriness or inhibition of function of transfused platelets. We monitored the survival and function of transfused platelets by flow cytometry and thrombelastography in a patient with GT. Gating on CD42a+ allowed identification of even a few transfused platelets. Only by gating on these CD41+ CD42a+ cells were w...

The purpose of pretransfusion compatibility testing is to prevent immune mediated hemolytic transfusion reactions. Our study aimed to evaluate the gel test for detection of clinically significant antibodies in repeatedly transfused patients. We investigated 200 thalassemic patients in whom, blood group, Rh-D, Rh phenotype determination, antibody screening and identification were done using an I...

background: b-thalassemia major is a serious medical problem. growth retardation is commonly seen in poly-transfused b- thalassemia patients. the exact mechanism of short stature in children with thalassemia major is not well understood, however, it is believed to be multi-factorial. objective: to study the growth state and its relationship to growth hormone (gh) deficiency in b-thalassemia pat...

Bone marrow transplantation (BMT) is now an option for some patients with sickle cell disease (SCD). Many SCD patients are multiply transfused with red blood cells (RBCs), and may be immunized to alloantigens other than erythrocyte antigens. Because platelet refractoriness is a significant complication during BMT, we wished to determine the prevalence of alloimmunization to platelets in transfu...

Objective; Prospective study to determine the prevalence of delayed puberty in thalassemia major patients in Sohag University Hospital. This study also aimed to determine serum gonadotropin and sex hormone levels in these patients and correlate these to their serum ferritin. Methods; This cross sectional study included 30 Thalassemia Major Patients, aged 12 to 18 years. Puberty was assessed cli...