Endodermal sinus tumor, also known as yolk sac tumor (YST), is a malignant germ cell tumor that most frequently occurs in the testis, the ovary, and sacrococcygeal areas in children. YSTs are highly aggressive and because of the early metastatic or invasive pattern, their prognosis has been poor. Treatment methods for YSTs are usually intensive, including multiagent chemotherapy, and have shown...

Conversions of leukemic cell lineage (lymphoid or myeloid) have been reported only rarely. Our review of the cytochemical and immunophenotypic features of 89 cases of childhood leukemia in marrow relapse indicated lineage switch (lymphoid to myeloid or the reverse) in six patients (6.7%). Five patients with acute lymphoblastic leukemia (ALL) at diagnosis had converted to acute nonlymphoblastic ...

We consider the programming of multiagent systems from an architectural perspective. Our perspective emphasizes the autonomy and heterogeneity of agents, the components of multiagent systems, and focuses on how to specify their interconnections in terms of high-level protocols. In this manner, we show how to treat the programming of a multiagent system as an architectural endeavor, leaving asid...

Multiagent systems are well suited to specify requirements for open physical complex systems. However, up to now, no method allows to build software/hardware hybrid multiagent systems. This paper presents an original method for designing physical multiagent systems. It advocates a basic multiagent phase able to tackle functionnal and organizational issues, associated to a componential phase for...

Expression of P-glycoprotein has been linked to multidrug resistance in cancer cell lines and human tumors. We investigated the frequency and clinical significance of P-glycoprotein immunoreactivity in 57 previ ously untreated diffuse large cell and immunoblastic lymphomas. Banked frozen tissue, which had been obtained prior to chemotherapy, was tested for reactivity with 2 monoclonal antibodie...

There is a growing awareness in the multiagent systems research community that the environment plays a prominent role in multiagent systems. Originating from research on behavior-based agent systems and situated multiagent systems, the importance of the environment in multiagent systems is now gradually accepted in the multiagent system community in general. The aim of the AgentLink Technical F...

The occurrence of deep-vein thrombosis (DVT) in patients with newly diagnosed multiple myeloma, who were randomly assigned to receive identical induction chemotherapy with or without thalidomide, are reported in this study. The 2 study arms were comparable with respect to key myeloma prognostic factors and known risk factors for DVT. One hundred patients received induction chemotherapy includin...