Background: Multidrug-resistant efflux pumps are one of the most significant methods by which bacteria can evade effects numerous antimicrobials. The aim this study was to determine prevalence multidrug-resistant MDR, extremely drug-resistant XDR, and pan-drug-resistant PDR K. pneumoniae phenotypes in clinical isolates, as well examine detection pump genes ompK35, ompK36, tolC, acrAB strains.&#...

New agents are needed with the increasing prevalence of multidrug-resistant (MDR) bacteria. Identification plants activity against MDR bacteria is importance. The antimicrobial commercially available Graviola preparations 38 clinical and laboratory isolates, representing drug-sensitive Gram positive negative bacteria, was measured by broth microdilution. Commercially fruit, as well leaves/stems...

Water containing ornamental fishes was found to frequently contain countable numbers of bacteria that were resistant to one or more antibiotic or chemotherapeutic agents. The multidrug-resistant strains most commonly isolated were lactose-fermenting Citrobacter freundii. The overall resistance of these aquaria strains was greater than the previously described resistance of clinical isolates of ...

Multidrug resistance constitutes a threat to the medical achievements of the last 50 years. In this study, we demonstrated the abilities of two de novo engineered cationic antibiotic peptides (eCAPs), WLBU2 and WR12, to overcome resistance from 142 clinical isolates representing the most common multidrug-resistant (MDR) pathogens and to display a lower propensity to select for resistant bacteri...

Background: Conducting surveillance of multidrug-resistant organisms leads to identifying changes in the pathogens causing healthcare-associated infections (HAIs) of specific sites, and the antimicrobial susceptibility patterns. This surveillance study aimed to characterize the pattern of nosocomial multidrug-resistant pathogens. Methods: Clinical laboratory reports from Chiang Mai University h...

Autophagy occurs in human neutrophils after the phagocytosis of multidrug-resistant bacteria and drug-sensitive strains, including Escherichia coli and Pseudomonas aeruginosa. The present study detected autophagy by immunoblot analysis of LC3B conversion, by confocal scanning microscopic examination of LC3B aggregate formation and by transmission electron microscopic examination of bacteria-con...

Background and Objective. Antimicrobial resistance is now a major challenge to clinicians for treating patients. Hence, this short term study was undertaken to detect the incidence of multidrug-resistant (MDR), extensively drug-resistant (XDR), and pandrug-resistant (PDR) bacterial isolates in a tertiary care hospital. Material and Methods. The clinical samples were cultured and bacterial strai...

We tested the effects of various putative efflux pump inhibitors on colistin resistance in multidrug-resistant Gram-negative bacteria. Addition of 10 mg/liter cyanide 3-chlorophenylhydrazone (CCCP) to the test medium could significantly decrease the MICs of colistin-resistant strains. Time-kill assays showed CCCP could reverse colistin resistance and inhibit the regrowth of the resistant subpop...

We conducted a prospective cohort study in a single tertiary hospital with the aim of assessing predictors of multidrug-resistant bacteremia in 307 cases of febrile neutropenia in adult patients with cancer. On multivariate analysis using stepwise logistic regression, age (P = .009), duration of neutropenia (P = .022), and presence of an indwelling central venous catheter (P = .022) were associ...