granular cell tumors are rare neoplasms of uncertain histogenesis but with a typical histologic appearance composed of cells with characteristic granular cytoplasm. these tumors occur most often in adults as an asymptomatic solitary papule or nodule. multiple granular cell tumors are rare, especially in children and teenagers. we represent a case of multiple granular cell tumors in a 19-year-ol...

optic neuritis occurs in young patients, most often females, and presents as subacute monocular visual loss. periocular pain, particularly with eye movement occurs in the majority of cases. the retrobulbar form occurs in 65% of cases and is associated with normal optic disc appearance at onset. the central visual field is usually affected and an rapd and dyschromatopsia are present. brain magne...

multiple sclerosis (ms) is an inflammatory disease of the central nervous system (cns). inflammation caused by immune cells destroy the myelin and then axon. cns failure to complete repair results in permanent disabilities. some types of stem cells have special potentials to repair these injuries and even cure ms. neural crest stem cells with a mutual origin with cns and the ability of differen...

melatonin has both pro-inflammatory and anti-inflammatory properties depending on the stage of inflammation. despite its therapeutic effect in alleviation of some symptoms of multiple sclerosis; the precise role of melatonin in ms pathogenesis remains a topic of debate. the aim of this study was to measure the urine level of one of melatonin products which is an index of serum melatonin level, ...

objective: multiple sclerosis (ms) is a chronic disease with prominent neurological and behavioral and psychiatric manifestations and unknown etiology which is demarcated with inflammation and destruction of white matter of brain and spinal cord and its replacement with gliotic tissue in young aged people and particularly females. the role of trace elements in multiple sclerosis is set forth in...

multiple sclerosis (ms) is an autoimmune disease that affects physical and emotional aspects of patient's lives. the aim of this study was to evaluate emotional intelligence (ei) in cases with ms.one hundred sixty six clinically definite ms and 110 healthy subjects were enrolled in this study. all participants filled valid and reliable persian version emotional quotient inventory (eq-i) questio...

multiple sclerosis (ms) is an autoimmune disease of the central nervous system associated to myelin loss and neurodegeneration. clinically patients suffer from diverse symptoms and face the risk to become wheelchair-bound. at the moment ms is incurable, thus there is an unmet need for therapeutic options.

conclusions the results of this study showed a possible association between cmv infection and ms. further experimental and epidemiological studies using case-control approaches are needed to confirm this association. results anti-cmv was positive in 65 (79.3%) and 69 (77.5%) of the ms patients and healthy subjects, respectively (p= 0.853). similarly, 23 (28%) and 2 (2.2%) patients were positive...

background: multiple sclerosis (ms), the most common demyelinating disease of the cns, is immunologically mediated in genetically susceptible individuals. receptors for the fc fragment of igg (fcγr) might induce inflammatory responses through linking the humoral and cellular immune responses by targeting immune complexes to effector cells. polymorphisms in some fcγr genes are associated with va...

sjogren-larsson syndrome (sls) is an inherited autosomal recessive neurocutaneous disorder with congenital ichthyosis, spastic diplegia or quadriplegia and mental retardation. we report a case of sjogren-larsson syndrome with clinical profile (mental retardation, ichthyosis, spastic diplegia) and mri findings such as seen in multiple sclerosis (ms). so this rare syndrome can be another differen...