The pharmacokinetics and safety of cefotetan (YM09330) were examined after intravenous administration of single and multiple doses to normal volunteers. Cefotetan was well tolerated in single doses of 500 to 3,000 mg and in multiple doses of 500 and 1,000 mg at 12-h intervals for 1 and 3 days. These doses produced high plasma levels. The half-life (3 h) of cefotetan was longer than that of cefa...

Zaltoprofen, a propionic acid derivative of non-steroidal anti-inflammatory drugs, has strong inhibitory effects on actue and chronic inflammation. A randomized, dose-escalating study was conducted to evaluate the pharmacokinetics of single and multiple oral doses of zaltoprofen in 12 healthy Chinese volunteers. Pharmacokinetics was determined from serial blood samples obtained up to 24 h after...

Objective: To assess the efficacy of Levofloxacin 500 mg orally for prophylaxis in transrectal prostate biopsy guided by ultrasonography compared to three dosages. Study design: A comparative study Place and Duration: this was done Murshid Hospital Health Care Centre Karachi from September 2021 2022 Methodology: total 615 patients having typical indications performed under guidance (increased P...

Background: Infectious complications after caesarean delivery (CD) are a substantial cause of maternal morbidity, increase in hospital stay and treatment cost. The spectrum these complications’ spreads from fever, wound infection, endometritis, urinary tract some serious like pelvic abscess, septic shock vein thrombophlebitis. To prevent prophylactic antibiotics have been used however the use s...

  Since the first report in 1977, many studies have been carried out to determine the efficacy of beta- blockers such as propranolol for the treatment of violent  and aggressive behaviour. Propranolol has also  been used in the treatment of dementia, attending- deficit disorder, schizophrenia, personality disorders, Korsakoff,s psychosis, posttraumatic stress disorder, profound mental retardat...

CMX001 is a novel, broad-spectrum lipid antiviral conjugate (LAC) that produces high intracellular levels of the active antiviral agent cidofovir diphosphate (CDV-PP). Study CMX001-102 was a randomized, double-blind, placebo-controlled, parallel group, dose-escalating study in healthy volunteers. The objectives of the study were to evaluate the safety and pharmacokinetic parameters of CMX001 af...