BACKGROUND AND PURPOSE Hypothermia reduces neuronal damage in animal stroke models. Whether hypothermia is neuroprotective in patients with acute stroke remains to be clarified. In this case-control study, we evaluated the feasibility and safety of inducing modest hypothermia by a surface cooling method in awake patients with acute stroke. METHODS We prospectively included 17 patients (cases)...

BACKGROUND The aim of this study was to analyse associations between educational level and delayed HIV diagnosis (DD), late initiation of combined antiretroviral therapy (cART), overall and in subjects with timely HIV diagnosis, virological and immunological responses to cART, and mortality from HIV diagnosis and cART initiation. METHODS This was a multicentre cohort study of HIV-positive tre...

We studied the incidence of type 1 diabetes in the offspring of patients with childhood- and adolescent-onset type 1 diabetes and several risk factors predicting the risk. We defined the diabetes status in the offspring of all probands who were included in the nationwide register of Finnish type 1 diabetic patients diagnosed at the age of < or =17 years from 1965 to 1979. A total of 5,291 offsp...

This report examines the predictive validity of sociometric status at age 9-10 to young adult (age 23-24) antisocial behavior, work and school engagement, and arrests using Oregon Youth Study males (N = 206). A variety of analytic strategies included (a) multivariate analyses to examine the variation in adult adaptation as a function of sociometric classification at age 9-10, (b) regression ana...

BACKGROUND The objectives for this study were to assess Oral Health Related Quality of Life (OHRQoL) in young people aged 15-25 who sought orthodontic treatment, and to measure the association between orthodontic treatment need (using the IOTN), sex, age and education level, and oral health related quality of life (OHRQoL). METHODS Survey of a consecutive series of 323 young adults aged 15 to...

Bootstrapping is a computer-intensive statistical method which treats the data set as a population and draws samples from it with replacement. This resampling method has wide application areas especially in mathematically intractable problems. In this study, it is used to obtain the empirical distributions of the parameters to determine whether they are statistically significant or not in a spe...