The traditional view of OA is that it is primarily a disease of articular cartilage that results, by altering the biomechanics of the joint, in secondary changes to the subchondral bone and, through secondary inflammation, other joint tissues. This focus on cartilage tends to ignore other musculoskeletal changes reported, especially those remote from affected joints. It has been proposed instea...

OBJECTIVE To evaluate the effects of belimumab versus placebo, plus standard systemic lupus erythematosus (SLE) therapy, on organ domain-specific SLE disease activity. METHODS Data obtained after 52 weeks of treatment from two phase III trials (BLISS-52 and BLISS-76) comparing belimumab 1 and 10 mg/kg versus placebo, plus standard therapy, in 1684 autoantibody-positive patients were analysed ...

Physical activity is a well-known therapeutic tool for various types of medical conditions, including vasculopathic diseases such as coronary artery disease, stroke, type 2 diabetes, and obesity. Additionally, increased physical activity has been proposed as a therapy to improve musculoskeletal health; however, there are conflicting reports about physical activity potentially leading to degener...

From the Orthopaedic Research Laboratories, Section of Orthopaedics, Department of Surgery, the Multipurpose Arthritis and Musculoskeletal Disease Center, and the Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor; and the Rheumatology Division, Department of Medicine, the Multipurpose Arthritis and Musculoskeletal Disease Center, and the Specialized Ce...

Objective. The primary objective of the study was to estimate the rates of polypharmacy among individuals with multimorbidity defined as chronic condition clusters and examine their associations with polypharmacy. Methods. Cross-sectional analysis of 10,528 individuals of age above 21, with at least one physical condition in cardiometabolic (diabetes or heart disease or hypertension), musculosk...

Arthritis and musculoskeletal conditions dominate the national illness burden worldwide. This chapter presents information on the different types of societal and individual impacts of musculoskeletal conditions, and describes the appropriate way to evaluate and present these effects. There are three types of 'costs' associated with musculoskeletal conditions: direct, indirect and intangible. Th...

Back pain is by far the most common ailment in working-age population, with WHO (2023) reporting that musculoskeletal disorders occur 80% of general mostly 30-50 age bracket, and advances technology increasing urban culture disease on rise.

With advances in the treatment of the mucopolysaccharidosis (MPS) disorders, musculoskeletal problems are increasingly becoming a focus of care for these patients. This review discusses the current understanding of the pathophysiology of musculoskeletal disease in MPS and its orthopedic management. Deformities of the spine, hips and extremities are common and often functionally limiting. Carpal...

Acute lymphocytic leukemia (ALL) may initially present with musculoskeletal symptoms such as pain or swelling, even before appearance of blasts in the peripheral blood. Fifteen to 30% of all ALL patients have musculoskeletal complaints at disease onset. Such presentation may lead to misdiagnosis of the patients causing a delay in proper management. Here, we present 5 patients who were referred ...

Melioidosis is an infectious disease caused by gram-negative soil-dwelling bacillus Burkholderia pseudomallei. Musculoskeletal melioidosis mimics other infections both clinically and radiologically. An extensive literature review has been performed over musculoskeletal melioidosis through various search engines such as Pubmed, Embase, Medscape, Altavista and Google. Diagnosis requires a high in...