This article discusses the role of electron microscopy in diagnosis and study morphological changes that cause platelet structural abnormalities a variety congenital diseases. Morphological can be divided into cytoskeleton, alpha dense granules, membrane abnormalities. Our paper describes ultrastructural defects Wiskott–Aldrich syndrome, MYH9-associated syndromes, gray Hermansky–Pudlak Paris–Tr...

Platelet transfusion is currently the primary medical treatment for reducing thrombocytopenia in patients with inherited thrombocytopenias. To evaluate whether stimulating megakaryopoiesis could increase platelet count in these conditions, we treated patients with a severe thrombocytopenia induced by MYH9 mutations (MYH9-related disease) with a nonpeptide thrombopoietin receptor agonist, eltrom...

doi:10.1160/TH11-07-0474 Thromb Haemost 2012; 107: 590–591 Dear Sirs, Fechtner syndrome (1) is a rare autosomaldominant disorder characterised by thrombocytopenia, giant platelets and features of Alport syndrome, i.e. nephritis, cataract and sensorineural hearing loss. It is one entity of a group of giant platelet disorders caused by mutations of the MYH9 gene, encoding the heavy chain of nonmu...

The world's population is growing and demand for food, feed, fiber, and fuel is increasing, placing greater demand on land and its resources for crop production. We review previously published estimates of global scale cropland availability, discuss the underlying assumptions that lead to differences between estimates, and illustrate the consequences of applying different estimates in model-bas...

A 19-year-old woman was addressed to the Haemophilia Treatment Center in august 2022 due thrombocytopenia on complete blood count (CBC). Medical examination did not reveal any signs of bleeding a daily basis, and she experienced appendectomy avulsion deciduous teeth without bleeding. ISTH assessment tool 0. There no family history or thrombocytopenia. CBC performed laboratory XN10 analyzer (Sys...

In vitro the antibacterial activity of the Acetone, Methanol and Ethanol extracts of three marine algae from Ennore beach near Chennai (coast of Tamil Nadu) were tested. The test organism includes Gram negative bacteria such as Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae and Gram positive bacteria such as Staphylococcus aureus. In this study, agar well diffusion test techniq...

Silicon micro-hole arrays (Si-MHA) were fabricated as a gas diffusion layer (GDL) in a micro fuel cell using the micro-electro-mechanical-systems (MEMS) fabrication technique. The resistance temperature detector (RTD) sensor was integrated with the GDL on a bipolar plate to measure the temperature inside the fuel cell. Experimental results demonstrate that temperature was generally linearly rel...