Medical diagnosis over the last decades have been reformed by tomographic imaging and has become a vital tool for diagnosis of several diseases. Magnetic particle imaging (MPI) as a new quantitative imaging method, uses the nonlinear re-magnetization behavior of magnetic nanoparticles to determine their local concentration. This paper presents an overview of a proposed method to design and cons...

  Objective: IQSPECT is an advanced high-speed SPECT modality for performing myocardial perfusion imaging (MPI), which uses a multi-focus fan beam collimator with resolution recovery reconstruction. The aim of this study was to compare IQSPECT compared with conventional SPECT interms of performance based on standard clinical protocols. In addition, we examined the concordance between convention...

Resovist originally developed as a clinical liver contrast agent for Magnetic Resonance Imaging exhibits also an outstanding performance as a tracer in Magnetic Particle Imaging (MPI). In order to study the physical mechanism of the high MPI performance of Resovist, we applied asymmetric flow field–flow fractionation (A4F) and static magnetic fractionation (SMF) to separate Resovist into a set ...

Myocardial Perfusion Imaging (MPI) is a non-invasive modality with proven diagnostic and prognostic utility in coronary artery disease. We present case of Transthyretin Amyloid Cardiomyopathy (ATTR-CM) where MPI findings were vastly different from Transthoracic Echocardiogram (TTE) Cardiac Magnetic Resonance (CMR). A 78-year-old gentleman presented atypical chest pain to rule out ischemic heart...

OBJECTIVES This study sought to evaluate the feasibility of noninvasive detection of matrix metalloproteinase (MMP) activity in experimental atherosclerosis using technetium-99m-labeled broad matrix metalloproteinase inhibitor (MPI) and to determine the effect of dietary modification and statin treatment on MMP activity. BACKGROUND The MMP activity in atherosclerotic lesions contributes to th...

OBJECTIVE The diagnostic yield of combined cardiopulmonary exercise testing (CPET) and myocardial perfusion imaging (MPI) in patients referred for stress testing has received limited study. METHODS We evaluated consecutive patients who underwent combined CPET-MPI at a single tertiary referral center between 2011 and 2015. An abnormal CPET was defined as any of the following: reduced oxygen co...

BACKGROUND Although high exercise tolerance is associated with an excellent prognosis, the significance of abnormal myocardial perfusion imaging (MPI) in patients with high exercise tolerance has not been established. This study retrospectively compares the utility of MPI and exercise ECG (EECG) in these patients. METHODS AND RESULTS Of 388 consecutive patients who underwent exercise MPI and ...

BACKGROUND Exercise electrocardiography (ETT) is frequently used in patients with suspected coronary artery disease (CAD). Single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) improves diagnostic stratification. There are no randomized trials comparing ETT and MPI. We hypothesized that first-line MPI would be effective and cost-saving versus ETT. METHODS AND R...

We investigated the diagnostic accuracy of computed tomography angiography (CTA) versus myocardial perfusion imaging (MPI) for detecting obstructive coronary artery disease (CAD) as defined by conventional quantitative coronary angiography (QCA). Sixty-three patients who were enrolled in the CorE-64 multicenter study underwent CTA, MPI, and QCA imaging. All subjects were referred for cardiac ca...

OBJECTIVES The aim of this study was to perform a head-to-head comparison between multi-slice computed tomography (MSCT) and myocardial perfusion imaging (MPI) in patients with an intermediate likelihood of coronary artery disease (CAD) and to compare non-invasive findings to invasive coronary angiography. BACKGROUND Multi-slice computed tomography detects atherosclerosis, whereas MPI detects...