Organ-on-a-chip (OOC) devices bring innovative disease modeling and drug discovery approaches by providing biomimetic models of tissues organs in vitro combined with biosensors. Miniaturized biosensor systems tissue biofabrication techniques allow to create multiple on a chip highly controlling the experimental variables for high-content screening applications. In this work, multi-OOC integrate...

1. Matsuo Y, Gleitsmann K, Mangner N, Werner S, Fischer T, Bowen TS, et al. Fibronectin type III domain containing 5 expression in skeletal muscle in chronic heart failure-relevance of inflammatory cytokines. J Cachexia Sarcopenia Muscle 2015;6:62–72. 2. Evans WJ, Morley JE, Argiles J, Bales C, Baracos V, Guttridge D, et al. Cachexia: a new definition. Clin Nutr 2008;27:793–799. 3. von Haehling...

Adult skeletal tissue is composed of heterogeneous population of cells that constantly self-renew by means of a controlled process of activation and proliferation of tissue-resident stem cells named satellite cells. Many growth factors, cytokines and myokines produced by skeletal muscle cells play critical roles in local regulation of the inflammatory process and skeletal muscle regeneration du...