To the Editor: Pretibial myxedema (PTM), a localized thyroid-associated dermopathy, is characterized by local thickening and remodeling of the skin − it is often associated with a group of autoimmune thyroid diseases (ATDs).[1] PTM is most frequently located across the lower legs, especially the pretibial areas or the dorsum of the foot. Rarely, the fingers and hands, elbows, arms, or face are ...

Background. Pretibial myxedema (PTM) is a rare dermopathy. The morphologic features and mechanism of its evolving process are not reported in large case series. Methods. 216 cases with PTM were retrospectively reviewed to analyze demographics, history, lesional morphology and its evolving process, histopathology and immunohistochemistry, serum TRAb levels, treatment, and outcome. Results. First...

I Department of Endocrinology, Faculty of Medical School, Fatih University Ankara, Turkey. II Department of Nephrology, Faculty of Medical School, Fatih University Ankara, Turkey. III Department of Internal Medicine, Faculty of Medical School, Fatih University Ankara, Turkey. Tel.: + 90-0312-4829166 or 2126262 Email: [email protected] A FORGOTTEN BUT IMPORTANT RISK FACTOR FOR SEVERE HY...

This review presents current knowledge about the thyroid emergencies known as myxedema coma and thyrotoxic storm. Understanding the pathogenesis of these conditions, appropriate recognition of the clinical signs and symptoms, and their prompt and accurate diagnosis and treatment are crucial in optimizing survival.

Endocrine emergencies are commonly encountered in the ICU. This article focuses on several important endocrine emergencies, including diabetic hyperglycemic states, adrenal insufficiency, myxedema coma, thyroid storm, and pituitary apoplexy. Other endocrine issues that are related to intensive care, such as intensive insulin therapy, relative adrenal insufficiency, and thyroid function test abn...

As is well recognized, activities of creatine kinase (CK, EC 2.7.3.2) and lactate dehydrogenase (EC 1.1.1.27) in plasma may be substantially increased in hypothyroidism. We emphasize here that an increase and decrease in CK-MB isoenzyme, characteristic of acute myocardial infarction, can occur in hypothermic myxedema coma without myocardial infarction.

Myxedema coma is a critical disorder with high mortality rates. Disruption of the compensatory mechanism for severe and long-term hypothyroidism by various causes leads to serious complications, including hypothermia, respiratory failure, circulatory central nervous system dysfunction. The most common myxedema are thought include infectious disease, stroke, myocardial infarction, sedative medic...