نتایج جستجو برای: nω hydroxy nor l arginine
تعداد نتایج: 764458 فیلتر نتایج به سال:
BACKGROUND l-Arginine is a semi-essential aminoacid with important role in regulation of physiological processes in humans. It serves as precursor for the synthesis of proteins and is also substrate for different enzymes such as nitric oxide synthase. This amino-acid act as free radical scavenger, inhibits the activity of pro-oxidant enzymes and thus acts as an antioxidant and has also bacteric...
atropine has been used to block cholinergic neurotransmission in basic research. large doses of atropine cause vasodilation of the blood vessels in the skin. this effect is apparently unconnected with the antimuscarinic activity of atropine and seems to be due to a direct action on the blood vessels. it has been suggested that atropine blocks muscarinic receptors at low doses and it induces the...
The objectives of the present study were to determine the mechanisms of antinociceptive effect of methanol extract of Clinacanthus nutans (Acanthaceae) leaves (MECN) using various animal nociceptive models. The antinociceptive activity of orally administered 10% DMSO, 100 mg/kg acetylsalicylic acid (ASA), 5 mg/kg morphine, or MECN (100, 250, and 500 mg/kg) was determined using the acetic acid-i...
A number of arylcysteine derivatives, which are metabolites of polycyclic aromatic hydrocarbons, have been synthesized. These amino acid analogs were tested for their ability to act as substrates for aminoacyl-RNA synthetases in an in vitro system using enzyme fractions of bakers' yeast. These studies have shown that 5-(p-chlorophenyl)-L-cysteine, 5-(9 ,10 dihydro-9-hydroxy-l 0-phenanthryl)-L-c...
We investigated the combined effect of dietary supplementation with L-arginine, which is the precursor of NO, and pharmacological treatment with atorvastatin, which is a 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitor, on the development of atherosclerosis in homozygous Watanabe heritable hyperlipidaemic rabbits. Rabbits were fed either standard rabbit chow (group C; n 9) as control, a...
AIMS Among people with diabetes, 10-25% will experience a foot ulcer. Research has shown that supplementation with arginine, glutamine and β-hydroxy-β-methylbutyrate may improve wound repair. This study tested whether such supplementation would improve healing of foot ulcers in persons with diabetes. METHODS Along with standard of care, 270 subjects received, in a double-blinded fashion, (twi...
BACKGROUND Transforming growth factor-beta(1) (TGF-beta(1)) contributes to arterial remodeling by stimulating vascular smooth muscle cell (VSMC) growth and collagen synthesis at sites of vascular injury. Because L-arginine is metabolized to growth-stimulatory polyamines and to the essential collagen precursor L-proline, we examined whether TGF-beta(1) regulates the transcellular transport and m...
Autophagic flux impairment is recently reported as a cardinal factor in acute pancreatitis (AP)pathogenesis. Niclosamide, an anthelmintic drug, has been lately proved to be potent autophagyenhancer. The diminution of the various inflammatory factors unrestrained release via autophagyimprovement may helpful improve prognosis AP. This study spots on investigating thepotential ameliorative effect ...
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