The antiarrhythmic activity of bis-alkoxyphenyltriazaalkanes 1 and bis-alkoxyphenyldiazaalkanes 2 was analyzed in a model reperfusion arrhythmia rats. It found that the key requirements for compounds this are use 2,3,4 trimethoxyphenyl aromatic pharmacophores presence central nitrogen atom linker. most active were ALM-802 (trihydrochloride N –(2,3,4-trimethoxybenzyl)-N – {2-[(2,3,4-trimethoxybe...

background: parathyroid hormone is an 84-amino acid peptide secreted by the parathyroid glands. its physiological role is maintenance of normal serum calcium level and bone remodeling. biological activity of this hormone is related to n-terminal 1-34 amino acids. the recombinant form of hormone (1-34) has been approved for treatment of osteoporosis from 2002. in this study, a novel fusion partn...