Metal ion interactions with nuclei acids and their constituents represent a multi-faceted growing research field. This contribution deals molecular recognition between synthetic purine 17 nucleosides first-row transition metal complexes, O- and/or N-amino chelators which are able to 18 engage in intra-molecular N-H···(N or O) O-H···(N interligand interactions. Crystals of these complexes can al...

Herein, a series of blue-emitting Ir(III) phosphors is reported based on the cyclometalating N-heterocyclic carbenes (NHCs), in which typical benzimidazolylidene entity now replaced by new 7,9-dihydro-8H-purin-8-ylidene unit. The two extra-nitrogen atoms that are successfully fined turn emission to true-blue region. As proof concept, both experimental measurement and theoretical calculation the...

Tetrahydro-4H-chromene-3-carbonitrile derivatives 4a-c where prepared from the reaction of 1,4-cyclohexane dione (1), malononitrile (2) and either benzaldehyde (3a), 2-chlorobenzaldehyde (3b) or 4-methoxybenzaldehyde (3c) in ethanol containing triethylamine. Compound 4b was used to prepare pyrazole, pyrimidine thiazole derivatives. Moreover, tetrahydrobenzo[d]thiazole derivative 18 (1) with ele...

Penelitian ini bertujuan untuk menyeleksi dan mendapatkan isolat jamur endofit dari tanaman nipah (Nypa fruticans) yang berdaya antagonis tinggi terhadap G. boninense penyebab penyakit busuk pangkal batang (BPB) pada kelapa sawit secara in vitro serta mengidentifikasinya hingga tingkat genus. dilakukan di Laboratorium Penyakit Tanaman Fakultas Pertanian Universitas Riau dimulai November 2020 Fe...

We describe an O(min(m,n3/2)m1/2)-time algorithm for finding maximum flows in undirected networks with unit capacities and no parallel edges. This improves upon the previous bound of Karzanov and Even and Tarjan when m = ω(n3/2), and upon a randomized bound of Karger when v = Ω(n7/4/m1/2).

X-ray crystallography, molecular modeling, and site-directed mutagenesis were used to delineate the catalytic mechanism of purine nucleoside phosphorylase (PNP). PNP catalyzes the reversible phosphorolysis of purine nucleosides to the corresponding purine base and ribose 1-phosphate using a substrate-assisted catalytic mechanism. The proposed transition state (TS) features an oxocarbenium ion t...

Chromosomal breakage resulting from stabilization of DNA topoisomerase II covalent complexes by epipodophyllotoxins may play a role in the genesis of leukemia-associated MLL gene translocations. We investigated whether etoposide catechol and quinone metabolites can damage the MLL breakpoint cluster region in a DNA topoisomerase II-dependent manner like the parent drug and the nature of the dama...