A D Cliff, M R Smallman-Raynor, P Haggett, D F Stroup and S B Thacker, Emergence and re-emergence: infectious diseases: a geographical analysis, Oxford University Press, 2009, pp. xxxvi, 764, £100.00 (hardback 978-0-19-924473-7). Horacio Fabrega Jr,History of mental illness in India: a cultural psychiatry retrospective, Indian Medical Tradition, vol. 10, Delhi, Motilal Banarsidass, 2009, pp. xx...

Background: Rybp (Ring1 and YY1 binding protein) is a zinc finger protein which interacts with the members of the mammalian polycomb complexes. Previously we have shown that Rybp is critical for early embryogenesis and that haploinsufficiency of Rybp in a subset of embryos causes failure of neural tube closure. Here we investigated the requirement for Rybp in ocular development using four in vi...

The basolateral nucleus of the amygdala (BLA) receives both noradrenergic and dopaminergic projections. These projections are thought to be important for modulation of amygdala neural circuits. In BLA pyramidal neurons, noradrenaline (NA) is known to facilitate gamma-aminobutyric acid (GABA)ergic spontaneous inhibitory postsynaptic currents (sIPSCs) through excitation of interneurons. Dopamine ...

Voltage-gated Na channels in several classes of neurons, including cells of the cerebellum, are subject to an open-channel block and unblock by an endogenous protein. The Na(V)beta4 (Scn4b) subunit is a candidate blocking protein because a free peptide from its cytoplasmic tail, the beta4 peptide, can block open Na channels and induce resurgent current as channels unblock upon repolarization. I...