Two men, the first aged 52 years and the second aged 72 years, were diagnosed during the reporting period as having habit-tic deformity. Because of similarities in the history and examination findings of these patients, I will discuss their cases jointly. Neither of the patients stated this problem was his chief concern, but on identification of the condition, both admitted it had been present ...

A 66-year-old male suffered from painful pustular eruptions of acrodermatitis continua of Hallopeau on bilateral thumbs for about 2 years, with associated nail dystrophy and markedly disabled manual skills. Initial treatment with topical corticosteroids, tars and calcipotriol failed to improve the acral lesions. Dapsone therapy began at a dose of 200 mg / day, which cleared the acral lesions wi...

We describe a fifty-six-year old, Afro-descendent female patient showing dystrophy of her twenty nails and hyperchromic, asymptomatic macule on her face. Histopathological examination of the macule showed vacuolization of the basal layer, melanophages in the superficial dermis and lymphoplasmocytic inflammatory infiltrate. Nail biopsy revealed orthokeratotic hyperkeratosis and lichenoid inflamm...

Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is caused by mutations in the autoimmune regulator (AIRE) gene, which has a central function in maintaining immunological tolerance. A number of conditions with proven or likely autoimmune pathogenesis occur in APECED: hypoparathyroidism, adrenocortical insufficency, candidiasis, hypogonadism, type 1 diabetes, hypothyroidis...

Pachyonychia congenita type 2 (PC-2) is an autosomal dominant disorder characterized by hypertrophic nail dystrophy, focal keratoderma, multiple pilosebaceous cysts, and other features of ectodermal dysplasia. It has been demonstrated that PC-2 is caused by mutations in the keratin 17 and keratin 6b genes. In this report, we describe a missense mutation in the keratin 17 gene, M88T, in a Korean...

OBJECTIVE To evaluate whether shoe-wearing affords foot protection among school children living in southern Ethiopia. METHODS Data collectors conducted a standardized foot assessment with children in an elementary school in southern Ethiopia (N=168). RESULTS 54% reported wearing shoes consistently in the prior three days. Children wearing closed-toed shoes showed less adherent soil and toe ...