Selectively delivering anticancer drugs to solid tumors while avoiding their accumulation in healthy tissues is a major goal polymeric micelle research. We have recently discovered that the extravasation and permeation of micelles occur dynamic manner characterized by vascular bursts followed brief vigorous outward flow fluid (called “nano-eruptions”). Nano-eruptions allow delivery micelle-asso...

Fluorophore molecules can be monitored by fluorescence spectroscopy and microscopy, which are highly useful and widely used techniques in cell biology, biochemistry, and medicine (e.g., biomarker analysis, immunoassays, cancer diagnosis). Several fluorescent micro- and nanoparticle systems based on block copolymer micelles and cross-linked polymer networks, quantum dots, π-conjugated polymers, ...

Abstract Background Chrysomycin A (CA) has been reported as numerous excellent biological activities, such antineoplastic and antibacterial. Though, poor solubility of CA limited its application in medical field. Due to good amphiphilicity potential anticancer effect disodium glycyrrhizin (Na 2 GA) an excipient, amorphous solid dispersion GA/CA-BM) consisting Na GA was prepared the present stud...

Front Cover: This special issue is dedicated to commemorate Wolfgang P. Meier, who had significant contributions in the fields of amphiphilic copolymer syntheses and their hierarchical self-assembly, block vesicles (so-called polymersomes), hybrid membranes. The self-assembly molecules generating nano- or micro-assemblies (membranes, micelles, vesicles, nanoparticles) that can be combined with ...

The central nervous system disorders represent a worldwide public health problem. Neuro-degeneration is associated with many transitions in brain including synaptic disorder and neuro-cognition decline. It shielded by barrier which controls the entry of compounds into known as blood (BBB), there regulating homeostasis. In achieving therapeutic amount drug to proper site action body then maintai...

BACKGROUND P-glycoprotein (P-gp) mediated drug efflux across the blood-brain barrier (BBB) is an important mechanism underlying poor brain penetration of certain antiepileptic drugs (AEDs). Nanomaterials, as drug carriers, can overcome P-gp activity and improve the targeted delivery of AEDs. However, their applications in the delivery of AEDs have not been adequately investigated. The objective...

Lipid-based photoantimicrobial supramolecular assemblies are promising structures for the development of new photodynamic treatments wound bacterial infections. Phenalenone (1H-phenalene-1-one, PN) has been used to obtain four stearoyl acid-based phenalenone derivatives (PNC18), with different types linkage and number acyl chains. After studying interfacial properties these compounds, nano-obje...

This article describes an accurate subPico flowmeter bifurcatedin to liquid and gas flowrates less than 1mol/s for both MEMS/NEMS and cryogenic technology applications. The MEMS/NEMS are described as either two Gauges (instrument), or quartz fluctuating forks, even if the liquid or gas flows through an element, as well as cryogenic technology consisting of arrays of e...

A new type of multifunctional polymeric micelle drug carrier for active intracellular drug delivery was prepared and characterized in this study. The micelle is a nano-supramolecular assembly with a spherical core-shell structure, and its surface and core were modified with piloting molecules for cancer cells and pH-sensitive drug binding linkers for controlled drug release, respectively. In or...