BACKGROUND Approximately 85% of nasal polyps (NPs) in white subjects are characterized by prominent eosinophilia. IL-5 is the key driver of eosinophilic differentiation and survival. OBJECTIVE We sought to investigate the therapeutic potential of inhibiting IL-5 with a humanized mAb as treatment for severe nasal polyposis. METHODS Thirty patients with severe nasal polyposis (grade 3 or 4 or...

OBJECTIVES We evaluated the efficacy of combined medical treatment in cases with bilateral nasal polyposis without a history of any surgical or medical treatment. PATIENTS AND METHODS Twenty-five patients (19 males, 6 females; mean age 45 years; range 30 to 60 years) who had not received any treatment for bilateral nasal polyposis were included. Treatment was comprised of an oral anti-histami...

BACKGROUND Topical glucocorticoids are the medical treatment of choice in a majority of patients suffering from nasal polyposis. Fluticasone propionate is a fluorinated steroid reported to be highly effective when used topically in the nose for seasonal and perennial allergic and nonallergic rhinitis. OBJECTIVES To evaluate the efficacy and tolerability of intranasal fluticasone propionate in...

OBJECTIVE To compare the 3-year results of 2 endoscopic surgical approaches in the management of nasal polyposis. DESIGN Retrospective medical record review. SETTING Private or institutional practice. PATIENTS A total of 127 patients with nasal polyposis were operated on by the same surgeon between January 1, 2003, and September 31, 2005. INTERVENTION The patients underwent radical ethm...

BACKGROUND A clear association between allergy and nasal polyposis (NP) is not determined and the role of food intolerance in patients with NP is not investigated by oral food challenge (OFC). OBJECTIVE To investigate the relation of salicylate food intolerance and atopy in patients with NP according to recurrence and aspirin sensitivity. METHODS A cross sectional multicenter study was done...

The incidence of rhinosinusitis and nasal polyposis is higher among asthmatic patients, probably because the pathogenesis of both conditions is characterized by eosinophilic infl ammation. Surgical treatment for polyps may be necessary when medical treatment is not effective, although relapses can occur even after surgery [1]. Omalizumab is a chimeric monoclonal anti-immunoglobulin E (anti-IgE)...