MOTIVATION Digital gene expression (DGE) technologies measure gene expression by counting sequence tags. They are sensitive technologies for measuring gene expression on a genomic scale, without the need for prior knowledge of the genome sequence. As the cost of sequencing DNA decreases, the number of DGE datasets is expected to grow dramatically. Various tests of differential expression have b...

Several purchase models are developed to understand customer dynamic purchasing behavior. The negative binomial distribution (NBD) contains two characteristics which are Poisson purchasing and gamma heterogeneity is shown as a robust method in product purchase frequency. An approach is to develop individual-level estimation by MCMC Bayesian NBD model. Since the smart phone launch to publish, va...

Although vegetable amaranth, Amaranthus viridis L. and A. dubius Mart. ex Thell., production and economic importance is increasing in diversified peri-urban farms in Jamaica, lepidopteran herbivory is common even during weekly pyrethroid applications. We developed and validated a sampling plan, and investigated insecticides with new modes of action, for a complex of five species (Pyralidae: Spo...

Introduction Leptospirosis has emerged as an important health problem in developing countries due to the growth of slum settlements worldwide, where poor sanitation favours rat-borne transmission. Large urban epidemics occur during seasonal periods of heavy rainfall. However, a detailed analysis has not been performed to determine how rainfall, as well as other climatic factors, specifically in...

BACKGROUND Airway microbiota dynamics during lower respiratory infection (LRI) are still poorly understood due, in part, to insufficient longitudinal studies and lack of uncontaminated lower airways samples. Furthermore, the similarity between upper and lower airway microbiomes is still under debate. Here we compare the diversity and temporal dynamics of microbiotas directly sampled from the tr...

1. We investigated the relationships of seed size, dispersal mode and other species characteristics to interspecific variation in mean primary seed dispersal distances, mean annual seed production per unit basal area, and clumping of seed deposition among 41 tropical tree species on Barro Colorado Island, Panama. 2. A hierarchical Bayesian model incorporating interannual variation in seed produ...

Assessment of treatment efficacy in metastatic castration-resistant prostate cancer (mCRPC) is limited by frequent nonmeasurable bone metastases. The count of circulating tumor cells (CTCs) is a promising surrogate marker that may replace the widely used prostate-specific antigen (PSA). The purpose of this study was to quantify the dynamic relationships between the longitudinal kinetics of thes...

Newly reported normalized cumulant moments of charged particles in ee collisions by the SLD collaboration are analyzed by the truncated modified negative binomial distribution (MNBD) and the negative binomial distribution (NBD). Calculated result by the MNBD describes the oscillatory behavior of the data much better than that by the NBD. PACS number(s): 13.65.+i, 34.10.+x Normalized cumulant mo...

MOTIVATION High-throughput RNA sequencing (RNA-seq) is now the standard method to determine differential gene expression. Identifying differentially expressed genes crucially depends on estimates of read-count variability. These estimates are typically based on statistical models such as the negative binomial distribution, which is employed by the tools edgeR, DESeq and cuffdiff. Until now, the...

Detection of differential expression in RNA-Seq data is currently limited to studies in which two or more sample conditions are known a priori. However, these biological conditions are typically unknown in cohort, cross-sectional and nonrandomized controlled studies such as the HapMap, the ENCODE or the 1000 Genomes project. We present DEXUS for detecting differential expression in RNA-Seq data...