background degenerative retinal diseases, including age related macular degeneration, glaucoma, and hereditary retinal dystrophies are major causes of blindness. the principal defect in these diseases is cell loss which is amenable to both cell based neuroprotective and neuroregenerative therapies. to briefly review the lines of research and potential candidates for cell based therapies among r...

elucidating the critical epigenetics events involved in differentiation and reprogramming of cells to primordial germ cells (pgcs) is among the interesting issues in stem cell research. here, i will talk about critical transcription factors and global hypomethylation in development of germ cells. evidence strongly suggests that the earliest pgcs emerging in the e7.25 mouse embryo epiblast have ...

backgrounds: a straight-forward way to identify whether a drug or environmental chemical can be harmful to unborn baby is to evaluate its effect on laboratory animals. all invivo methods need large number of animal and are therefore time consuming and expensive. however, the thousands of chemicals in need of testing, to reduce the spending of live animals, an assortment of in vitro assays has b...

the introduction and evolution of hematopoietic stem cell transplantation (hsct) could be traced back to 1950s, to the studies on interactions among irradiation, covering spleen and bone marrow from it and injection of bone marrow cells. today, hsct is considered a well-established, effective and promising means of therapy for various malignant and non-malignant medical conditions, both in chil...

background:  renal transplantation is the best choose in the end stage renal disease (esrd), and acute rejection and graft dysfunction remain major challenges in the worldwide, even with the advent of new immunosuppressive drugs. the novel cell-based anti-rejection treatments have been studied by using different stem cell sources. in this study, transplantation of autologous-bone-marrow-derived...

introduction brain trauma is one of the most common causes of hospitalization, disability, and mortality of people aged 15 to 74 years in nowadays societies. on the other hand, nowadays, different categories of stem cells are used to treat different kinds of diseases. bm-mscs, are center of scientific research because of their high differentiation and proliferation ability. methods:  stem cells...

introduction: during the last decade, advances in tissue engineering and stem cell-based tooth regeneration have provided realistic and attractive means of replacing lost or damaged teeth. the first adult stem cells isolated from dental tissues were dental pulp stem cells (dpscs). when transplanted with hydroxyl apatite/tri calcium phosphate (ha/tcp) powder, they formed a dentin-like structure ...

background :gelatin and chitosan are known as biodegradable and biocompatible biopolymers.these biopolymers have recently receivedincreasingly more attention for tissueengineering.the aim of this study was to evaluate the toxicity effects of gelatin-chitosan film on bone marrow stromal cell(bmscs) culture in rat.                                                  materials & methods: first, gelat...

introduction:   mesenchymal stem cells have the potential of self-renewal and differentiation into different cell types, including blood cells, heart, nerves and cartilage, and have unlimited power for division. these cells can be obtained from cord, before implantation from fertilized cells and also from various tissues of adults although the differentiation power and the ability to reproduce ...

background: pancreatic islet transplantation has emerged as a promising treatment for type i diabetes. however, its efficacy is severely hampered due to poor islet engraftment and revascularization, which have been resulted to partially loss of transplanted islets. it has been shown that local delivery of vascular endothelial growth factor (vegf) could accelerate transplanted islet revasculariz...