The necrotizing disease occurs in parts of West Africa, Australia and Southeast Asia, affecting around 5,000 people each year [1]. Children aged under 15 are the most commonly infected demographic group and the region with the highest concentration of infections is, currently, Cote d'Ivoire. Until the late 1990s, when World Health Organization (WHO) programs began, the disease was a 'neglected ...

Investment in the development of new vaccines is suboptimal. Changing this situation requires a creative blend of "push" and "pull" strategies. One successful policy model is the Orphan Drug Act, whose key features include large research and development (R and D) tax credits as well as Food and Drug Administration (FDA) counseling and priority review. Such supply-side R and D incentive provisio...