in this work, one and two-dimensional lattices are studied theoretically by a statistical mechanical approach. the nearest and next-nearest neighbor interactions are both taken into account, and the approximate thermodynamic properties of the lattices are calculated. the results of our calculations show that: (1) even though the next-nearest neighbor interaction may have an insignificant effect...

The nociceptin/orphanin FQ (NOP) receptor is involved in a wide range of biological functions, including pain, anxiety, depression and drug abuse. Especially, its agonists have great potential to be developed into anxiolytics. In this work, both the ligand- and receptor-based three-dimensional quantitative structure-activity relationship (3D-QSAR) studies were carried out using comparative mole...

Effects of the investigational methane (CH 4 ) inhibitor 3-nitrooxypropanol (3-NOP) on animal performance, health and enteric CH production beef cattle were evaluated in a commercial feedlot. Two concurrent studies conducted: large pen study (4,048 cattle, eight replicates per experimental group) to measure performance small (a subset 50 from study, n = 25 emissions. Within animals (body weight...

Cebranopadol (trans-6'-fluoro-4',9'-dihydro-N,N-dimethyl-4-phenyl-spiro[cyclohexane-1,1'(3'H)-pyrano[3,4-b]indol]-4-amine) is a novel analgesic nociceptin/orphanin FQ peptide (NOP) and opioid receptor agonist [Ki (nM)/EC50 (nM)/relative efficacy (%): human NOP receptor 0.9/13.0/89; human mu-opioid peptide (MOP) receptor 0.7/1.2/104; human kappa-opioid peptide receptor 2.6/17/67; human delta-opi...

Intracerebroventricular nociceptin/orphanin FQ (N/OFQ) produces cardiovascular depressor, diuretic, and renal sympathoinhibitory responses in conscious rats. These studies examined how a chronic high-NaCl intake alters these peptide-evoked responses and the activity of the endogenous central N/OFQ peptide (NOP) receptor system. In normotensive Sprague-Dawley rats fed a chronic (3-wk) high (8%)-...

C appreciate that there is interplay between the actions of the different subtypes of receptor and hence the value of drugs which target multiple receptor subtypes. Abstract The opioid system comprises four receptor subtypes: m (MOP), k (KOP), d (DOP), now called the ‘classical’ opioid receptors, and the ‘non classical’ nociceptin/orphanin FQ peptide (N/OFQ) receptor (NOP). Selective endogenous...

Among the shortcomings of A* algorithm, for example, there are many search nodes in path planning, and calculation time is long. This article proposes a three-neighbor algorithm combined with artificial potential fields to optimize planning problem mobile robots. The integrates improves partial field address irregular obstacles forward direction. guides robot move quickly. method performs accur...

Any connected plane nearest neighbor graph has diameter Ω(n). This bound generalizes to Ω(n) in any dimension d. For any set of n points in the plane, we define the nearest neighbor graph by selecting a unique nearest neighbor for each point, and adding an edge between each point and its neighbor. This is a directed graph with outdegree one; thus it is a pseudo-forest. Each component of the pse...

Neighbor-joining is one of the most widely used methods for constructing evolutionary trees. This approach from phylogenetics is often employed in population genetics, where distance matrices obtained from allele frequencies are used to produce a representation of population relationships in the form of a tree. In phylogenetics, the utility of neighbor-joining derives partly from a result that ...