Research of protein is pivotal to the drug discovery, since most of the drugs act upon proteins inside human body. Drugs act when they are close to the concave portions, so called “pockets”, of protein surfaces. Therefore, detection and analysis of the pockets are also important for the drug discovery. This paper presents a fast pocket extraction and evaluation technique for protein surfaces. S...

this paper describes an optimal design for multivariable pi controller with a high gain structure for an irregular system by genetic algorithm. pi controllers with a high gain structure leads to the asymptotic decomposition of the fast and slow modes in the closed loop system that have unique characteristics. the slow modes are asymptotically uncontrollable and unobservable; therefore, they hav...

pore network modeling uses a network of pores connected by throats to model the void space of a porous medium and tries to predict its various characteristics during multiphase flow of various fluids. in most cases, a non-realistic regular lattice of pores is used to model the characteristics of a porous medium. although some methodologies for extracting geologically realistic irregular network...

We introduce irregular constructible sheaves, which are $\mathbb{C}$-constructible with coefficients in a finite version of Novikov ring $\Lambda$ and special gradings. show that the bounded derived category cohomologically complexes is equivalent to holonomic $\mathcal{D}$-modules by modification D'Agnolo--Kashiwara's Riemann--Hilbert correspondence. The equipped perverse t-structure, straight...