Recently, we characterized neoamphimedine (neo) as an ATP-competitive inhibitor of the ATPase domain of human Topoisomerase IIα. Thus far, neo is the only pyridoacridine with this mechanism of action. One limiting factor in the development of neo as a therapeutic agent has been access to sufficient amounts of material for biological testing. Although there are two reported syntheses of neo, bot...

Age and Gender on Social Media Language, behavior and health correlate with age and gender • Women tend to live longer (CDC, 2014); people, with age, tend to be more agreeable, more conscientious and less open to experience (McCrae et al. 1999) • most social scientific studies on social media data use biased samples of age and gender There is a need for accessible tools to predict demographic v...

Antihemorroidal hubber Leuco hubber Panotile Bacisporín Linitul antibiótico Poly-pred Bexicortil Liquipom dexa-antibiótico Pomada antibiótica liade Bio-hubber/fuerte Maxitrol Positon crema Blastoestimulina óvulos Neo-analsona Positon crema Blastoestimulina pomada Neo-bacitrin Potison loción Creanolona Neo-bacitrin hidrocortisona Positon ungüento Decadran neomicina Neo-hubber Rinobanedif Deltaci...

Rhodopsin is formed by the condensation of opsin with a cis isomer of retinene, called neo-b. The bleaching of rhodopsin releases all-trans retinene which must be isomerized back to neo-b in order for rhodopsin to regenerate. Both retinene isomers are in equilibrium with the corresponding isomers of vitamin A, through the alcohol dehydrogenase system. An enzyme is found in cattle retinas and fr...

Die Anwendung Remote Task Control entstand in Zusammenarbeit der Firmen HORSCH und geo-konzept im Forschungsprojekt Geo Farm und ermöglicht eine durchgängig automatisierte Prozesskette von der Bereitstellung und Archivierung georeferenzierter Applikationskarten und Datenübertragung zur Landmaschine bis zur Ausführung und Dokumentation des variablen Applikationsprozesses im Feld. Das Projekt Geo...

objectives: multiple sclerosis is an incurable and chronic disease of the central nervous system. the main purpose of this survey is to compare the character types and life expectancy of patients suffering from m. s as compared with normal people. this survey was conducted using the persian translation of neo-ffi (neo-five factor inventory) and herth life expectancy. methods:thirty nine people ...

In most phylogenetic lineages, the evolution of sex chromosomes is accompanied by their heteromorphization and degradation of one of them. The neo-sex chromosomes are useful model for studying early stages of these processes. Recently two lineages of the neo-sex chromosomes on different stages of heteromorphization was discovered in Pamphagidae family. The neo-sex chromosome heteromorphization ...

Individuals with dementia are often passive, which places them at risk for further cognitive and functional decline. Recreational activities have been used in research to reduce passive behaviors, but systematic reviews of these studies have found modest effect sizes for many activities. In this article, we describe the further theoretical development of an innovative method for prescribing act...

Unlike adult damage, neonatal damage to the inferior prefrontal convexity (IC) in monkeys spares learning and performance on the delayed nonmatching-to-sample (DNMS) task ( Málková et al. 2000). We investigated whether this sparing was due to compensation by undamaged orbital frontal cortex (O), an area also critical for DNMS, by comparing combined IC and O damage (Neo-ICO) with damage to O alo...