OBJECTIVES We sought to assess the prevalence and progression of neo-aortic root dilation and valvar regurgitation after staged reconstruction for hypoplastic left heart syndrome (HLHS). BACKGROUND In HLHS, the pulmonary valve functions as the neo-aortic valve. Neo-aortic valve dysfunction has been observed after arterial switch operation and the Ross procedure. METHODS Patients with HLHS b...

It is shown that the problem of source and essence morality most satisfactorily solved on basis metaphysics Platonism. Its concrete implementation in form a fundamental physical theory relational paradigm theoretical physics. A number consequences have been developed from interpretation as transcendent connection person with First Cause being for religious philosophy social ideology.

Cell cycle checkpoints are evolutionarily conserved signaling pathways that uphold genomic integrity. Complete inactivation of the mouse checkpoint gene Hus1 results in chromosomal instability, genotoxin hypersensitivity, and embryonic lethality. To determine the functional consequences of partial Hus1 impairment, we generated an allelic series in which Hus1 expression was incrementally reduced...

OBJECTIVE After the arterial switch operation (ASO), disproportional neo-aortic growth during childhood has been reported. Even though it has been suggested neo-aortic dilation will stabilise in adulthood, data are lacking. The aim of this study was to assess the change in neo-aortic dimensions, prevalence of neo-aortic dilation >40 mm and long-term outcome in adults who underwent ASO in childh...

In this paper, I argue that various disputes in ontology have important ramifications and so are worth taking seriously. I employ a criterion according to which whether a dispute matters depends on how integrated it is with the rest of our theoretical projects. Disputes that arise from previous tensions in our theorizing and have additional implications for other issues matter, while insular di...

Mathematical concepts play at least three roles in the application of mathematics: an inferential role, a representational role, and an expressive role. In this paper, I argue that, despite what has often been alleged, platonists do not fully accommodate these features of the application of mathematics. At best, platonism provides partial ways of handling the issues. I then sketch an alternativ...