[PDF] [Full Text] [Abstract] , September 20, 2010; . Cereb. Cortex Xiaoming Jin, John R. Huguenard and David A. Prince Epileptogenic Neocortex Reorganization of Inhibitory Synaptic Circuits in Rodent Chronically Injured [PDF] [Full Text] [Abstract] , May , 2011; 21 (5): 1094-1104. Cereb. Cortex Xiaoming Jin, John R. Huguenard and David A. Prince Epileptogenic Neocortex Reorganization of Inh...

The work in progress reported by Wright & Liley shows great promise, primarily because of their experimental and simulation paradigms. However, their tentative conclusion that macroscopic neocortex may be considered (approximately) a linear nearequilibrium system is premature and does not correspond to tentative conclusions drawn from other studies of neocortex.

EEG and single-unit techniques have been used to study the EEG correlates of cellular firing in the neocortex, n. reticularis (RT) and "specific" thalamic nuclei, and the cholinergic forebrain area (nucleus basalis, NB). Neuronal firing was related to the ongoing behavior of the rat. In addition, using a 16-channel neocortical recording/mapping system, we studied the effects of ibotenic acid le...

APP23 transgenic mice express mutant human amyloid precursor protein and develop amyloid plaques predominantly in neocortex and hippocampus progressively with age, similar to Alzheimer's disease. We have previously reported neuron loss in the hippocampal CA1 region of 14- to 18-month-old APP23 mice. In contrast, no neuron loss was found in neocortex. In the present study we have reinvestigated ...

Prompted by considerations about (i) the compositionality of cognitive functions. (ii) the physiology of individual cortical neurons, (iii) the role of accurately timed spike patterns in wrtex, and (iv) the regulation of global conical activity, we suggest that the dynamics of cartex on the 1-ms time scale may be described as the activation of circuits of the synfrechain type (Abeles 1982, 1991...

more than an outstanding scientist who contributed greatly to our knowledge of the histopathology of various brain diseases. He was “first and foremost a psychiatrist who strove to advance psychiatry by using a microscope”. Contrary to the growing movement that regarded disabled people as inferior, Alzheimer treated his patients with great compassion. Today, Alzheimer’s name is associated with ...

Although sensory perception and neurobiology are traditionally investigated one modality at a time, real world behaviour and perception are driven by the integration of information from multiple sensory sources. Mounting evidence suggests that the neural underpinnings of multisensory integration extend into early sensory processing. This article examines the notion that neocortical operations a...