Diabetic nephropathy can be identified as diabetes mellitus's furthermost significant complications. Tne End-Stage Renal Disease is also a result of diabetic nephropathy. The first-line therapy for patients with accompanied by proteinuria renin-angiotensin-aldosterone system inhibition. possible renoprotective effect evaluation valsartan/ sacubitril (ARNI) on model induced in rats compared ...

Oxalate nephropathy is commonly caused by ethylene glycol, vitamin C, and foods like star fruit that contain a lot of oxalate. Peanuts also have high oxalate contents. However, case reports of peanut-induced oxalate nephropathy are not common. Here, we describe a case of peanut-induced acute oxalate nephropathy with acute kidney injury and intend to demonstrate the conditions under which peanut...

Oxidative stress contributes to the pathogenesis of diabetic nephropathy. In mitochondria, lipoic acid synthase produces α-lipoic acid, an antioxidant and an essential cofactor in α-ketoacid dehydrogenase complexes, which participate in glucose oxidation and ATP generation. Administration of lipoic acid abrogates diabetic nephropathy in animal models, but whether lower production of endogenous ...

Although diabetic nephropathy occurs only in a minority of diabetic patients (approximately 30%), it is the major single cause of end-stage renal disease in the United States. Hyperglycemia and hypertension are important factors predisposing patients to nephropathy, however, accumulating evidence points to critical genetic factors that predispose only a subset of diabetic patients to nephropath...

OBJECTIVE Toll-like receptor 4 (TLR4) plays a central role in innate immunity. Activation of innate immune response and subsequent chronic low-grade inflammation are thought to be involved in the pathogenesis of diabetic nephropathy. In this study, we aimed to investigate whether TLR4 variants are associated with diabetic nephropathy in the Chinese population. METHODS Seven tagging single nuc...

Diabetes is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) in most parts of the world. 20 to 30% of diabetic patient have diabetic nephropathy in type 1 and type 2. Hyperglycemia is the key of nephropathy creation. Hyperglycemia also by production of toxic materials, advanced glycosylated end product (AGE), increased activity of aldose reductase has som...

BACKGROUND Genetic factors are suspected in the pathogenesis of IgA nephropathy, as well as in the course of IgA nephropathy progression towards end stage renal failure. UMOD polymorphism rs12917707 is known to associate with end stage renal failure of mixed aetiologies. METHODS We tested a large cohort of Caucasian patients for association of rs12917707 with IgA nephropathy showing a benign,...

BACKGROUND Despite the development of biomarkers and noninvasive imaging tools, biopsy remains the only method for correctly diagnosing patients with unexplained hematuria, proteinuria and renal failure. Renal biopsy has been performed for several decades in Taiwan; however, a national data registry is still lacking until 2013. METHODS The Renal Biopsy Registry Committee was established withi...

4þ haematuria, but urinary sediments showed few red blood cells (1-2-1/high-power fields). His renal function recovered concomitantly with improvement of haemolytic anaemia; thus, haemolysis might also have contributed to the development of his renal dysfunction. Indeed, haemolysisrelated renal dysfunction has occurred in patients with HCV infection [1]. Our patient showed cryoglobulinaemia, bu...

AIMS The prevalence of diabetic nephropathy and its risk factors have not been studied in a society known to have diabetes epidemic like Saudi Arabia. Using a large data base registry will provide a better understanding and accurate assessment of this chronic complication and its related risk factors. METHODOLOGY A total of 54,670 patients with type 2 diabetes aged ≥ 25 years were selected fr...